SCHEMBL17230899

SCHEMBL17230899

CCCCCCCCCCCCCCCCOc1cc(C(=O)n2c(=O)c(C)cn([C@H]3C[C@@H](OC(=O)CCC(C)=O)[C@@H](CO)O3)c2=O)cc(OCCCCCCCCCCCCCCCC)c1OCCCCCCCCCCCCCCCC

nearest known ligand 0.43

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
RNASE1 P07998 1/20 0.38
SLC6A2 P23975 1/20 0.36
TK2 O00142 4/20 0.36
PRKCA P17252 5/20 0.34
CA12 O43570 1/20 0.31
CA5A P35218 1/20 0.31
CA7 P43166 1/20 0.31
CA5B Q9Y2D0 1/20 0.31
THRA P10827 1/20 0.31
THRB P10828 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17230947 0.94 RNASE1 (0.38) RNASE1SLC6A2TK2PRKCACA12
SCHEMBL17231038 0.88 RNASE1 (0.38) RNASE1SLC6A2TK2PRKCACA12
SCHEMBL20987601 0.86 RNASE1 (0.41) RNASE1SLC6A2
SCHEMBL29703141 0.86 TK2 (0.39) TK2
SCHEMBL17231013 0.84 RNASE1 (0.39) RNASE1SLC6A2TK2CA12CA5A
SCHEMBL17230917 0.83 RNASE1 (0.32) RNASE1TK2PRKCA
SCHEMBL19565366 0.80 TOP2A (0.32) TK2THRATHRB
SCHEMBL17230822 0.79 TYMP (0.32) RNASE1
SCHEMBL20987564 0.77 RNASE1 (0.32) RNASE1
SCHEMBL22472268 0.76 RNASE1 (0.51) RNASE1SLC6A2TK2CA12CA5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150315229-A1 METHOD FOR LIQUID-PHASE SYNTHESIS OF NUCLEIC ACID TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2015-11-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150315229-A1 METHOD FOR LIQUID-PHASE SYNTHESIS OF NUCLEIC ACID POLM, POLRMT, RNMT RNASE1 121/4885SLC6A2 3978/4885TK2 303/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.