Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | CNR2 | P34972 | 2/20 | 0.50 |
| ▸ | FNTA | P49354 | 1/20 | 0.50 |
| ▸ | FNTB | P49356 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL317792 | 0.93 | LMNA (0.48) | LMNAKMT2AHPGDPKMMEN1 | |
| SCHEMBL13064496 | 0.88 | LMNA (0.58) | LMNAKMT2AHPGDPKMMEN1 | |
| SCHEMBL13064487 | 0.88 | LMNA (0.69) | LMNAKMT2AHPGDPKMMEN1 | |
| SCHEMBL303319 | 0.87 | LMNA (0.48) | LMNAKMT2AHPGDPKMMEN1 | |
| SCHEMBL13064393 | 0.81 | LMNA (0.60) | LMNAKMT2AHPGDPKMMEN1 | |
| SCHEMBL303420 | 0.81 | LMNA (0.72) | LMNAKMT2AHPGDCNR2ALDH1A1 | |
| SCHEMBL3456953 | 0.81 | LMNA (0.79) | LMNAKMT2AHPGDCNR2ALDH1A1 | |
| SCHEMBL13064391 | 0.81 | LMNA (0.58) | LMNAKMT2AHPGDPKMMEN1 | |
| SCHEMBL2214743 | 0.80 | VNN1 (0.47) | LMNAKMT2AHPGDPKMMEN1 | |
| SCHEMBL13065216 | 0.79 | LMNA (0.63) | LMNAKMT2AHPGDPKMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344456-A1 | NOVEL POTASSIUM CHANNEL BLOCKER | Xention Limited (GB) | 2011-07-20 | — | — | EP | disclosed |