Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VNN1 | O95497 | 2/20 | 0.47 |
| ▸ | RHOA | P61586 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | SPR | P35270 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL302916 | 0.92 | KMT2A (0.46) | VNN1KMT2AMEN1CYP3A4PKM | |
| SCHEMBL303319 | 0.90 | LMNA (0.48) | KMT2AMEN1CYP3A4PKMLMNA | |
| SCHEMBL302831 | 0.89 | CYP3A4 (0.45) | RHOAKMT2AMEN1CYP3A4PKM | |
| SCHEMBL2246857 | 0.80 | MEN1 (0.65) | KMT2AMEN1PKMLMNAALDH1A1 | |
| SCHEMBL1723232 | 0.80 | LMNA (0.54) | KMT2AMEN1CYP3A4PKMLMNA | |
| SCHEMBL2186628 | 0.79 | GRM5 (0.49) | KMT2AMEN1LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL301712 | 0.79 | GRM5 (0.52) | KMT2AMEN1PKMLMNAALDH1A1 | |
| SCHEMBL2209547 | 0.79 | LMNA (0.43) | KMT2ALMNAALDH1A1SPRHTT | |
| SCHEMBL13064516 | 0.79 | LMNA (0.60) | KMT2AMEN1PKMLMNAHPGD | |
| SCHEMBL2188728 | 0.79 | SPR (0.49) | KMT2AMEN1PKMLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2342177-B1 | NOVEL POTASSIUM CHANNEL BLOCKERS | JAPAN TOBACCO INC (JP) | 2017-02-15 | — | — | EP | claimed |
| EP-2342177-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | Xention Limited (GB) | 2011-07-13 | — | — | EP | disclosed |