Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | FNTA | P49354 | 1/20 | 0.44 |
| ▸ | FNTB | P49356 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | BCR | P11274 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2214743 | 0.90 | VNN1 (0.47) | LMNAKMT2AMEN1L3MBTL1PKM | |
| SCHEMBL302916 | 0.89 | KMT2A (0.46) | LMNAKMT2AMEN1L3MBTL1PKM | |
| SCHEMBL302831 | 0.88 | CYP3A4 (0.45) | LMNAKMT2AMEN1L3MBTL1PKM | |
| SCHEMBL1723232 | 0.87 | LMNA (0.54) | LMNAKMT2AMEN1L3MBTL1PKM | |
| SCHEMBL13064516 | 0.87 | LMNA (0.60) | LMNAKMT2AMEN1PKMHPGD | |
| SCHEMBL13065202 | 0.86 | CNR2 (0.60) | LMNAKMT2AMEN1PKMHPGD | |
| SCHEMBL2246857 | 0.86 | MEN1 (0.65) | LMNAKMT2AMEN1PKMCNR2 | |
| SCHEMBL3379160 | 0.82 | LMNA (0.49) | LMNAKMT2AMEN1PKMCNR2 | |
| SCHEMBL13065200 | 0.81 | LMNA (0.52) | LMNAKMT2AMEN1PKMHPGD | |
| SCHEMBL301712 | 0.81 | GRM5 (0.52) | LMNAKMT2AMEN1PKMHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2342177-B1 | NOVEL POTASSIUM CHANNEL BLOCKERS | JAPAN TOBACCO INC (JP) | 2017-02-15 | — | — | EP | claimed |
| JP-2012500836-A | — | — | 2012-01-12 | — | — | JP | claimed |
| EP-2342177-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | Xention Limited (GB) | 2011-07-13 | — | — | EP | claimed |
| EP-2342177-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | Xention Limited (GB) | 2011-07-13 | — | — | EP | disclosed |