Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 12/20 | 0.69 |
| ▸ | POLB | P06746 | 4/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17233490 | 0.85 | TRPM8 (0.62) | TRPM8POLBATMALDH1A1TP53 | |
| SCHEMBL17233485 | 0.85 | TRPM8 (0.67) | TRPM8POLBATMALDH1A1TP53 | |
| SCHEMBL19892467 | 0.84 | TRPM8 (0.56) | TRPM8POLBATMALDH1A1TP53 | |
| SCHEMBL20902815 | 0.83 | TRPM8 (0.64) | TRPM8POLBATMALDH1A1TP53 | |
| SCHEMBL17233493 | 0.83 | TRPM8 (0.68) | TRPM8POLBATMALDH1A1TP53 | |
| SCHEMBL17233500 | 0.83 | TRPM8 (0.82) | TRPM8POLBALDH1A1 | |
| SCHEMBL17233487 | 0.82 | TRPM8 (0.61) | TRPM8POLBATMALDH1A1TP53 | |
| SCHEMBL17233501 | 0.82 | TRPM8 (0.59) | TRPM8POLBATMALDH1A1TP53 | |
| SCHEMBL2730417 | 0.82 | TRPM8 (1.00) | TRPM8 | |
| SCHEMBL30582844 | 0.82 | TRPM8 (1.00) | TRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170087199-A1 | COMPOSITIONS FOR DELIVERING A COOLING SENSATION | SENOMYX INC (US) | 2017-03-30 | — | — | US | disclosed |
| US-20160339026-A1 | TOPICAL COMPOSITIONS COMPRISING MODULATORS OF TRPM8 | SENOMYX INC (US) | 2016-11-24 | — | — | US | disclosed |
| US-20160317532-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | FIRMENICH INCORPORATED | 2016-11-03 | — | — | US | disclosed |
| US-9394287-B2 | Compounds useful as modulators of TRPM8 | SENOMYX, INC. (US) | 2016-07-19 | — | — | US | disclosed |
| US-20150313820-A1 | PREPARATIONS | SYMRISE AG (DE) | 2015-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160317532-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | TRPM8, TRPM7, TRPM6 | TRPM8 1/4885POLB 4439/4885ATM 3262/4885 |
| US-20170087199-A1 | COMPOSITIONS FOR DELIVERING A COOLING SENSATION | TRPA1, PDE6G, PDE6D | TRPM8 97/4885POLB 3252/4885ATM 1766/4885 |
| US-20160339026-A1 | TOPICAL COMPOSITIONS COMPRISING MODULATORS OF TRPM8 | TRPM8, TRPM7, TRPM2 | TRPM8 1/4885POLB 2854/4885ATM 2508/4885 |
| US-20150313820-A1 | PREPARATIONS | CRAT, ACAT2, TAS2R50 | TRPM8 101/4885POLB 1657/4885ATM 3224/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.