Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MME | P08473 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | DRD4 | P21917 | 2/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.37 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 2/20 | 0.37 |
| ▸ | MMP1 | P03956 | 2/20 | 0.37 |
| ▸ | MMP9 | P14780 | 2/20 | 0.36 |
| ▸ | MMP8 | P22894 | 2/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1723473 | 0.73 | HTR2A (0.46) | MTNR1AMTNR1BHTR2AHTR6TDP1 | |
| SCHEMBL1723469 | 0.73 | GAA (0.56) | MTNR1AMTNR1BHTR2AHTR6TDP1 | |
| SCHEMBL5202211 | 0.72 | MTNR1A (0.52) | MTNR1AMTNR1BHTR2AHTR6SCN5A | |
| SCHEMBL6775637 | 0.72 | MTNR1A (0.59) | MTNR1AMTNR1BHTR2AHTR6SCN5A | |
| SCHEMBL2013301 | 0.71 | MTNR1A (0.58) | MTNR1AMTNR1BHTR2AHTR6SCN5A | |
| SCHEMBL6775913 | 0.71 | MTNR1A (0.58) | MTNR1AMTNR1BHTR2AHTR6SCN5A | |
| SCHEMBL23226249 | 0.70 | HTR2A (0.60) | MTNR1AMTNR1BHTR2AHTR6SCN5A | |
| SCHEMBL28409765 | 0.70 | SMN1; SMN2 (0.60) | MTNR1AMTNR1BHTR2AHTR6SCN5A | |
| SCHEMBL24328917 | 0.70 | SMN1; SMN2 (0.60) | MTNR1AMTNR1BHTR2AHTR6SCN5A | |
| SCHEMBL24328893 | 0.70 | MTNR1A (0.57) | MTNR1AMTNR1BHTR2AHTR6SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957454-B1 | METHODS FOR SYNTHESIS OF 3-AMINO-1-ARYLPROPYL INDOLES | HOFFMANN LA ROCHE (CH) | 2011-07-20 | — | — | EP | disclosed |