SCHEMBL5202211

SCHEMBL5202211

CNC(=O)C(Cc1c[nH]c2cccc(OC)c12)C1CCCCC1

nearest known ligand 0.52

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 1/20 0.52
MTNR1B P49286 1/20 0.52
HTR2A P28223 3/20 0.47
HTR6 P50406 1/20 0.43
DRD2 P14416 2/20 0.41
DRD4 P21917 2/20 0.41
DRD3 P35462 2/20 0.41
NMBR P28336 1/20 0.41
TP53 P04637 1/20 0.41
POLB P06746 1/20 0.41
MAPT P10636 1/20 0.41
ECE1 P42892 1/20 0.41
SCN5A Q14524 1/20 0.40
SCN2A Q99250 1/20 0.40
TACR1 P25103 3/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2071662 0.76 MTNR1A (0.42) MTNR1AMTNR1BHTR2AHTR6DRD2
SCHEMBL6775637 0.73 MTNR1A (0.59) MTNR1AMTNR1BHTR2AHTR6DRD2
SCHEMBL6775913 0.72 MTNR1A (0.58) MTNR1AMTNR1BHTR2AHTR6DRD2
SCHEMBL2013301 0.72 MTNR1A (0.58) MTNR1AMTNR1BHTR2AHTR6MAPT
SCHEMBL1723472 0.72 MTNR1A (0.47) MTNR1AMTNR1BHTR2AHTR6DRD2
SCHEMBL24328917 0.72 SMN1; SMN2 (0.60) MTNR1AMTNR1BHTR2AHTR6DRD2
SCHEMBL28409765 0.72 SMN1; SMN2 (0.60) MTNR1AMTNR1BHTR2AHTR6DRD2
SCHEMBL24328893 0.72 MTNR1A (0.57) MTNR1AMTNR1BHTR2AHTR6DRD2
Hydrochloric Acid SCHEMBL28174732 0.71 MTNR1A (0.57) MTNR1AMTNR1BHTR2AHTR6MAPT
Hydrochloric Acid SCHEMBL28174730 0.71 MTNR1A (0.57) MTNR1AMTNR1BHTR2AHTR6MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1756054-A1 3-AMINO-1-ARYLPROPYL INDOLES AS MONOAMINE REUPTAKE INHIBITOR F.HOFFMANN-LA ROCHE AG (CH) 2007-02-28 EP disclosed
WO-2005118539-A1 3-AMINO-1-ARYLPROPYL INDOLES AS MONOAMINE REUPTAKE INHIBITOR F.HOFFMANN-LA ROCHE AG (CH) 2005-12-15 WO disclosed