Ammonia Solution, Strong

Ammonia Solution, Strong

SCHEMBL1723530

CCCCF.N.O.O.O

nearest known ligand 0.00

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Ammonia Solution, Strong. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ammonia Solution, Strong SCHEMBL8549003 1.00
Ammonia Solution, Strong SCHEMBL524152 0.96
Hydrochloric Acid SCHEMBL9763208 0.92
SCHEMBL45362 0.92
SCHEMBL12111341 0.92
SCHEMBL12111337 0.92
SCHEMBL27702029 0.88
SCHEMBL27769735 0.88
SCHEMBL27348093 0.88
Phosphine SCHEMBL28154723 0.88

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2406227-A1 PROCESS FOR MANUFACTURING 5-(2-{[6-(2,2-DIFLUORO-2-PHENYLETHOXY) HEXYL]AMINO}-1- HYDROXYETHYL)-8-HYDROXYQUINOLIN-2(1H)-ONE. Almirall S.A. (ES) 2012-01-18 EP claimed
WO-2010102831-A1 PROCESS FOR MANUFACTURING 5-(2-{[6-(2,2-DIFLUORO-2-PHENYIETHOXY) HEXYL]AMINO}-L- HYDROXYETHYL)-8-HYDROXYQUINOLIN-2(1H)-ONE. ALMIRALL, S.A. (ES) 2010-09-16 WO claimed
US-10669538-B2 Templated molecules and methods for using such molecules NUEVOLUTION A/S (DK) 2020-06-02 US disclosed
US-20170198283-A1 TEMPLATED MOLECULES AND METHODS FOR USING SUCH MOLECULES NUEVOLUTION A/S (DK) 2017-07-13 US disclosed
EP-3010591-B1 CATIONIC GROUP-CONTAINING CELLULOSE ETHER KAO CORP (JP) 2017-04-12 EP disclosed
US-9456977-B2 Cationized glycerolated cellulose KAO CORPORATION (JP) 2016-10-04 US disclosed
EP-3010591-A1 CATIONIC GROUP-CONTAINING CELLULOSE ETHER Kao Corporation (JP) 2016-04-27 EP disclosed
US-20150064128-A1 CATIONIZED GLYCEROLATED CELLULOSE KAO CORPORATION (JP) 2015-03-05 US disclosed
EP-2825263-A1 CATIONISED GLYCEROLATED CELLULOSE Kao Corporation (JP) 2015-01-21 EP disclosed
US-8932992-B2 Templated molecules and methods for using such molecules NUEVOLUTION A/S (DK) 2015-01-13 US disclosed
WO-2014203548-A1 CATIONIC GROUP-CONTAINING CELLULOSE ETHER KAO CORPORATION (JP) 2014-12-24 WO disclosed
US-20100016177-A1 TEMPLATED MOLECULES AND METHODS FOR USING SUCH MOLECULES NUEVOLUTION A/S (DK) 2010-01-21 US disclosed
EP-1940775-A2 METHODS AND COMPOSITIONS FOR THE EFFICIENT DELIVERY OF THERAPEUTIC AGENTS TO CELLS AND ANIMALS University of Massachusetts (US) 2008-07-09 EP disclosed
US-20070260055-A1 Methods and compositions for the efficient delivery of therapeutic agents to cells and animals NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2007-11-08 US disclosed
WO-2007022030-A2 METHODS AND COMPOSITIONS FOR THE EFFICIENT DELIVERY OF THERAPEUTIC AGENTS TO CELLS AND ANIMALS UNIVERSITY OF MASSACHUSETTS (US) 2007-02-22 WO disclosed
US-5952478-A Intermediates for dinucleotide and oligonucleotide analogues NOVARTIS FINANCE CORPORATION (US) 1999-09-14 US disclosed
US-4665193-A HYPOTENSIVE AGENTS E. R. SQUIBB & SONS, INC. (US) 1987-05-12 US disclosed
US-4629724-A HYPOTENSIVE AGENTS E. R. SQUIBB & SONS, INC. (US) 1986-12-16 US disclosed
US-4616088-A Amino acid ester and amide renin inhibitor E. R. SQUIBB & SONS, INC. (US) 1986-10-07 US disclosed
EP-0181071-A2 Amino acid ester and amide renin inhibitors E.R. Squibb &amp; Sons, Inc. (US) 1986-05-14 EP disclosed