Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.35 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 4/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.32 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.32 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.32 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.31 |
| ▸ | MAP1LC3A | Q9H492 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1710752 | 0.87 | BCHE (0.38) | AGTR2CTSK | |
| SCHEMBL1724792 | 0.86 | IL1B (0.36) | ROCK2P2RX7 | |
| SCHEMBL16031201 | 0.85 | GCK (0.36) | ROCK2AGTR2L3MBTL1MAP1LC3BMAP1LC3A | |
| SCHEMBL16031904 | 0.85 | AGTR2 (0.35) | AGTR2CTSKMAP1LC3BMAP1LC3A | |
| SCHEMBL1710613 | 0.85 | PNMT (0.32) | ROCK2AGTR2 | |
| SCHEMBL16031844 | 0.80 | HPGD (0.34) | AGTR2CTSKMAP1LC3BMAP1LC3A | |
| SCHEMBL3390167 | 0.78 | CTSK (0.37) | AGTR2CTSK | |
| SCHEMBL13400259 | 0.78 | HDAC6 (0.38) | CTSK | |
| SCHEMBL13400239 | 0.78 | HDAC6 (0.38) | CTSK | |
| SCHEMBL1710885 | 0.77 | BCHE (0.37) | CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344451-A2 | SULFUR-LINKED COMPOUNDS FOR TREATING OPTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010028088-A2 | SULFUR-LINKED COMPOUNDS FOR TREATING OPTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2010-03-11 | — | — | WO | disclosed |