Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | ECE1 | P42892 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3392036 | 0.79 | ALDH1A1 (0.38) | ECE1TDP1 | |
| SCHEMBL22206877 | 0.78 | SLC22A6 (0.38) | GAATDP1 | |
| SCHEMBL28240410 | 0.77 | ALOX15 (0.40) | GAACHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL23771194 | 0.76 | CHRNB2 (0.38) | GAACHRNB2CHRNB4CHRNA4 | |
| SCHEMBL12189857 | 0.76 | LMNA (0.33) | TDP1 | |
| SCHEMBL15946666 | 0.76 | GAA (0.33) | GAA | |
| SCHEMBL14655206 | 0.74 | CHRNB2 (0.36) | CHRNB2CHRNB4CHRNA3CHRNA4ECE1 | |
| SCHEMBL3477951 | 0.74 | CHRNB2 (0.36) | CHRNB2CHRNB4CHRNA3CHRNA4ECE1 | |
| SCHEMBL14166969 | 0.74 | CHRNB2 (0.36) | CHRNB2CHRNB4CHRNA3CHRNA4ECE1 | |
| SCHEMBL27917872 | 0.74 | USP2 (0.37) | CHRNB2CHRNB4CHRNA3CHRNA4TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3649106-A1 | N-(3-(2-(4-CHLOROPHENOXY)ACETAMIDO)BICYCLO[1.1.1]PENTAN-1-YL)-2-CYCLOBUTANE-1-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ATF4 INHIBITORS FOR TREATING CANCER AND OTHER DISEASES | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2020-05-13 | — | — | EP | claimed |
| WO-2019008506-A1 | N-(3-(2-(4-CHLOROPHENOXY)ACETAMIDO)BICYCLO[1.1.1]PENTAN-1-YL)-2-CYCLOBUTANE-1-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ATF4 INHIBITORS FOR TREATING CANCER AND OTHER DISEASES | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-01-10 | — | — | WO | claimed |
| EP-2403856-A1 | METHYLENEDIOXYBENZO [I]PHENANTHRIDINE DERIVATIVES USED TO TREAT CANCER | Rutgers, The State University of New Jersey (US) | 2012-01-11 | — | — | EP | claimed |
| WO-2010102219-A1 | METHYLENEDIOXYBENZO [I] PHENANTHRIDINE DERIVATIVES USED TO TREAT CANCER | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2010-09-10 | — | — | WO | claimed |