Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 5/20 | 0.39 |
| ▸ | CTSL | P07711 | 4/20 | 0.39 |
| ▸ | CTSB | P07858 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
| ▸ | TACR3 | P29371 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | KCNA3 | P22001 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28951054 | 0.86 | CTSK (0.49) | LMNAMAOAMAOBCTSKCTSL | |
| SCHEMBL7531427 | 0.84 | CTSK (0.50) | LMNAMAOAMAOBCTSKCTSL | |
| SCHEMBL4825666 | 0.78 | HSD17B3 (0.44) | MAOAMAOBMEN1CYP2C9KMT2A | |
| SCHEMBL28607722 | 0.77 | LMNA (0.39) | LMNAMAOAMAOBCTSKCTSL | |
| SCHEMBL3857434 | 0.76 | CTSK (0.42) | LMNAMAOAMAOBCTSKCTSL | |
| SCHEMBL28280874 | 0.76 | CTSL (0.34) | LMNAMAOAMAOBCTSKCTSL | |
| SCHEMBL3864730 | 0.75 | OPRM1 (0.46) | MEN1KMT2A | |
| SCHEMBL1881050 | 0.74 | CTSK (0.43) | LMNAMAOAMAOBCTSKCTSL | |
| SCHEMBL11808804 | 0.72 | KMT2A (0.44) | LMNAMAOAMAOBMEN1CYP2C9 | |
| SCHEMBL14379186 | 0.72 | OPRL1 (0.50) | MAOAMAOBMEN1CYP2C9KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403857-A1 | THIENOPYRIMIDINE AS CDC7 KINASE INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2012-01-11 | — | — | EP | disclosed |