Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 8/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.42 |
| ▸ | PRKCQ | Q04759 | 6/20 | 0.42 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.42 |
| ▸ | PRKCB | P05771 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | PRKCH | P24723 | 1/20 | 0.41 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17255760 | 0.83 | LTA4H (0.45) | SRCHTR1APRKCQPRKCDHTR1B | |
| SCHEMBL2975469 | 0.81 | RET (0.47) | SRCHTR1APRKCQHTR1BRET | |
| SCHEMBL2986267 | 0.77 | RET (0.45) | SRCHTR1APRKCQHTR1BRET | |
| SCHEMBL17255752 | 0.77 | TSHR (0.51) | HTR1ASLC6A4HTR1BRET | |
| SCHEMBL2982161 | 0.76 | RET (0.54) | PRKCQPRKCDHTR1BRETJAK2 | |
| SCHEMBL2971119 | 0.73 | PRKCQ (0.75) | PRKCQPRKCDPRKCBLCKPRKCH | |
| SCHEMBL14358832 | 0.73 | HTR1A (0.55) | HTR1ASLC6A4ADRA1DADRA1AADRA1B | |
| SCHEMBL17255748 | 0.72 | POLB (0.54) | PRKCQPRKCDPRKCBLCKPRKCH | |
| SCHEMBL17255759 | 0.72 | HTR1A (0.46) | HTR1APRKCQPRKCDHTR1BJAK2 | |
| SCHEMBL17255761 | 0.71 | PRKCQ (0.51) | SRCPRKCQPRKCDPRKCBLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029543-B1 | SUBSTITUTED 3-CYANOPYRIDINES AS PROTEIN KINASE INHIBITORS | WYETH LLC (US) | 2015-11-18 | — | — | EP | disclosed |