Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | HTR1B | P28222 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 4/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2986267 | 0.86 | RET (0.45) | RETHTR1BJAK2JAK3HTR1A | |
| SCHEMBL2982161 | 0.85 | RET (0.54) | RETHTR1BJAK2JAK3MAPK14 | |
| SCHEMBL17255752 | 0.83 | TSHR (0.51) | RETHTR1BHTR1ADRD2DRD4 | |
| SCHEMBL17255754 | 0.81 | SRC (0.46) | RETHTR1BJAK2JAK3HTR1A | |
| SCHEMBL2980702 | 0.80 | ULK1 (0.45) | RETJAK2MAPK14PRKCQTUBB4A | |
| SCHEMBL17255769 | 0.80 | PRKCQ (0.46) | RETHTR1BJAK2JAK3MAPK14 | |
| SCHEMBL4073823 | 0.77 | HTR1B (0.60) | HTR1BHTR1ADRD2DRD4DRD3 | |
| SCHEMBL1545429 | 0.72 | HTR1B (0.60) | HTR1BHTR1ADRD2DRD4DRD3 | |
| SCHEMBL7876385 | 0.70 | HTR1B (0.58) | HTR1BHTR1ADRD2DRD4DRD3 | |
| SCHEMBL9130728 | 0.70 | HDAC3 (0.52) | MEN1MAPTMAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781591-B2 | Substituted 3-cyanopyridines as protein kinase inhibitors | WYETH LLC (US) | 2010-08-24 | — | — | US | claimed |