Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | HTR1B | P28222 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 5/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.45 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2975469 | 0.83 | RET (0.47) | DRD2DRD4DRD3HTR1BHTR1A | |
| SCHEMBL2986267 | 0.81 | RET (0.45) | DRD2DRD4DRD3HTR1BHTR1A | |
| SCHEMBL2982161 | 0.80 | RET (0.54) | L3MBTL1HTR1BRET | |
| SCHEMBL17255754 | 0.77 | SRC (0.46) | HTR1BHTR1ASLC6A4RET | |
| SCHEMBL9096899 | 0.73 | HTR1A (0.65) | TSHRDRD2DRD4DRD3HTR1B | |
| SCHEMBL9132886 | 0.68 | HTR1A (0.48) | L3MBTL1DRD2DRD4DRD3HTR1B | |
| SCHEMBL11534872 | 0.68 | ALDH1A1 (0.79) | TSHRL3MBTL1DRD2DRD4DRD3 | |
| SCHEMBL17255750 | 0.67 | EGFR (0.44) | — | |
| SCHEMBL10413109 | 0.67 | DHPS (0.47) | DRD2DRD4DRD3HTR1BHTR1A | |
| SCHEMBL10591827 | 0.67 | HTR1B (0.58) | TSHRDRD2DRD4DRD3HTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029543-B1 | SUBSTITUTED 3-CYANOPYRIDINES AS PROTEIN KINASE INHIBITORS | WYETH LLC (US) | 2015-11-18 | — | — | EP | disclosed |