Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | USP5 | P45974 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17269944 | 0.83 | GPR119 (0.53) | — | |
| SCHEMBL17262478 | 0.80 | EPHX2 (0.43) | HTTNAMPTLMNAEPHX2NR1H4 | |
| SCHEMBL18428446 | 0.80 | HTT (0.43) | HTTKMT2ANAMPTCNR2LMNA | |
| SCHEMBL17269945 | 0.79 | HTT (0.47) | HTTKMT2ANAMPTCNR2EPHX2 | |
| SCHEMBL4974364 | 0.78 | ALDH1A1 (0.40) | HTTLMNAEPHX2 | |
| Hydrochloric Acid SCHEMBL18428444 | 0.78 | HTT (0.46) | HTTKMT2ANAMPTCNR2EPHX2 | |
| SCHEMBL18469711 | 0.74 | ENPP2 (0.54) | KMT2A | |
| SCHEMBL4978743 | 0.72 | LMNA (0.38) | HTTKMT2ALMNA | |
| SCHEMBL16565618 | 0.71 | ATM (0.49) | HTTKMT2AUSP5 | |
| SCHEMBL20069691 | 0.70 | FAAH (0.46) | HTTKMT2ACNR2LMNAHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3134079-A1 | SUBSTITUTED N-(2-(AMINO)-2-OXOETHYL)BENZAMIDE INHIBITORS OF AUTOTAXIN AND THEIR PREPARATION AND USE IN THE TREATMENT OF LPA-DEPENDENT OR LPA-MEDIATED DISEASES | X-RX Discovery, Inc. (US) | 2017-03-01 | — | — | EP | disclosed |
| WO-2015175171-A1 | SUBSTITUTED N-(2-(AMINO)-2-OXOETHYL)BENZAMIDE INHIBITORS OF AUTOTAXIN AND THEIR PREPARATION AND USE IN THE TREATMENT OF LPA-DEPENDENT OR LPA-MEDIATED DISEASES | X-RX DISCOVERY, INC. (US) | 2015-11-19 | — | — | WO | disclosed |