Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACSS2 | Q9NR19 | 20/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31668345 | 1.00 | ACSS2 (1.00) | ACSS2 | |
| SCHEMBL30060694 | 1.00 | ACSS2 (1.00) | ACSS2 | |
| SCHEMBL18674939 | 1.00 | ACSS2 (1.00) | ACSS2 | |
| SCHEMBL18662748 | 1.00 | ACSS2 (1.00) | ACSS2 | |
| SCHEMBL17267123 | 0.95 | ACSS2 (1.00) | ACSS2 | |
| SCHEMBL18675078 | 0.94 | ACSS2 (0.88) | ACSS2 | |
| SCHEMBL18674897 | 0.93 | ACSS2 (1.00) | ACSS2 | |
| SCHEMBL29917914 | 0.93 | ACSS2 (0.87) | ACSS2 | |
| SCHEMBL18675062 | 0.92 | ACSS2 (0.86) | ACSS2 | |
| SCHEMBL18675072 | 0.92 | ACSS2 (1.00) | ACSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4121423-B1 | TETRAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2026-04-29 | — | — | EP | disclosed |
| EP-4121429-B1 | CONDENSED PYRIDINE DERIVATIVES SUBSTITUED BY AMIDE FUNCTIONS AS ACSS2 INHIBITORS | MERCK PATENT GMBH (DE) | 2025-08-13 | — | — | EP | disclosed |
| US-20250243168-A1 | ACETYL-COA SYNTHETASE 2 (ACSS2) INHIBITORS AND METHODS USING SAME | THE WISTAR INST (US) | 2025-07-31 | — | — | US | disclosed |
| US-12281084-B2 | Acetyl-CoA synthetase 2 (ACSS2) inhibitors and methods using same | THE WISTAR INSTITUTE (US) | 2025-04-22 | — | — | US | disclosed |
| US-20240382468-A2 | TETRAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2024-11-21 | — | — | US | disclosed |
| US-20240009175-A9 | TETRAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2024-01-11 | — | — | US | disclosed |
| US-20230271956-A1 | AMIDE DERIVATIVES | MERCK PATENT GMBH (DE) | 2023-08-31 | — | — | US | disclosed |
| US-20230149371-A1 | TETRAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2023-05-18 | — | — | US | disclosed |
| EP-4121423-A1 | TETRAZOLE DERIVATIVES | Merck Patent GmbH (DE) | 2023-01-25 | — | — | EP | disclosed |
| EP-4121429-A1 | CONDENSED PYRIDINE DERIVASTIVES SUBSTITUED BY AMIDE FUNCTIONS AS ACSS2 INHIBITORS | Merck Patent GmbH (DE) | 2023-01-25 | — | — | EP | disclosed |
| WO-2021185793-A1 | TETRAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2021-09-23 | — | — | WO | disclosed |
| WO-2021185789-A1 | CONDENSED PYRIDINE DERIVASTIVES SUBSTITUED BY AMIDE FUNCTIONS AS ACSS2 INHIBITORS | MERCK PATENT GMBH (DE) | 2021-09-23 | — | — | WO | disclosed |
| WO-2020252407-A1 | ACETYL-COA SYNTHETASE 2 (ACSS2) INHIBITORS AND METHODS USING SAME | THE WISTAR INSTITUTE (US) | 2020-12-17 | — | — | WO | disclosed |
| US-10040767-B2 | Benzimidazole derivatives and uses thereof | PELOTON THERAPEUTICS, INC. (US) | 2018-08-07 | — | — | US | disclosed |
| US-10040767-B2 | Benzimidazole derivatives and uses thereof | PELOTON THERAPEUTICS, INC. (US) | 2018-08-07 | — | — | US | disclosed |
| US-10040767-B2 | Benzimidazole derivatives and uses thereof | PELOTON THERAPEUTICS, INC. (US) | 2018-08-07 | — | — | US | disclosed |
| US-20170088523-A1 | BENZIMIDAZOLE DERIVATIVES AND USES THEREOF | PELOTON THERAPEUTICS, INC. | 2017-03-30 | — | — | US | disclosed |
| US-20170088523-A1 | BENZIMIDAZOLE DERIVATIVES AND USES THEREOF | PELOTON THERAPEUTICS, INC. | 2017-03-30 | — | — | US | disclosed |
| US-20170088523-A1 | BENZIMIDAZOLE DERIVATIVES AND USES THEREOF | PELOTON THERAPEUTICS, INC. | 2017-03-30 | — | — | US | disclosed |
| WO-2015175845-A1 | BENZIMIDAZOLE DERIVATIVES AND USES THEREOF | PELOTON THERAPEUTICS, INC. (US) | 2015-11-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170088523-A1 | BENZIMIDAZOLE DERIVATIVES AND USES THEREOF | ACSS2, GLS2, ACSL3 | ACSS2 1/4885 |
| US-20240009175-A9 | TETRAZOLE DERIVATIVES | VHL, BRCA1, POT1 | ACSS2 3202/4885 |
| US-20240382468-A2 | TETRAZOLE DERIVATIVES | VHL, BRCA1, POT1 | ACSS2 3202/4885 |
| US-12281084-B2 | Acetyl-CoA synthetase 2 (ACSS2) inhibitors and methods using same | ACSS2, ACACB, ACACA | ACSS2 1/4885 |
| US-20230271956-A1 | AMIDE DERIVATIVES | BRCA1, HRAS, PCNA | ACSS2 201/4885 |
| US-20230149371-A1 | TETRAZOLE DERIVATIVES | VHL, BRCA1, POT1 | ACSS2 3202/4885 |
| US-10040767-B2 | Benzimidazole derivatives and uses thereof | ACSS2, GLS2, ACSL3 | ACSS2 1/4885 |
| US-20250243168-A1 | ACETYL-COA SYNTHETASE 2 (ACSS2) INHIBITORS AND METHODS USING SAME | ACSS2, ACACB, ACACA | ACSS2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.