Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.33 |
| ▸ | UBE2M | P61081 | 1/20 | 0.33 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.33 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
| ▸ | SCN1A | P35498 | 1/20 | 0.33 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 2/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | WNK1 | Q9H4A3 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1726750 | 0.76 | MEN1 (0.48) | UBE2MDCUN1D1CCR2MCHR1MEN1 | |
| SCHEMBL1725571 | 0.75 | DRD2 (0.38) | LSSUBE2MDCUN1D1CCR2FAAH | |
| SCHEMBL1726868 | 0.73 | UBE2M (0.35) | CHRM2CHRM3UBE2MDCUN1D1CCR2 | |
| SCHEMBL1844021 | 0.71 | WNK1 (0.43) | LSSUBE2MDCUN1D1CCR2WNK1 | |
| SCHEMBL1844023 | 0.68 | MEN1 (0.53) | LSSUBE2MDCUN1D1CHRM4MEN1 | |
| SCHEMBL1727312 | 0.62 | MCHR1 (0.44) | CHRM4MCHR1KCNH2MEN1LMNA | |
| SCHEMBL12153529 | 0.62 | MCHR1 (0.44) | CHRM4MCHR1KCNH2MEN1LMNA | |
| SCHEMBL12153544 | 0.61 | MCHR1 (0.43) | CHRM4MCHR1KCNH2MEN1LMNA | |
| SCHEMBL12153653 | 0.61 | MCHR1 (0.44) | UBE2MDCUN1D1CCR2MCHR1MEN1 | |
| SCHEMBL5577706 | 0.60 | PROKR1 (0.52) | CHRM4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10034476-B2 | Insecticidal phenyl-or pyridyl-piperdine compounds | SYNGENTA PARTICIPATIONS AG (CH) | 2018-07-31 | — | — | US | disclosed |
| US-20170347650-A1 | INSECTICIDAL PHENYL-OR PYRIDYL-PIPERDINE COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2017-12-07 | — | — | US | disclosed |
| US-9808006-B2 | Insecticidal phenyl-or pyridyl-piperdine compounds | SYNGENTA PARTICIPATIONS AG (CH) | 2017-11-07 | — | — | US | disclosed |
| US-20130317062-A1 | INSECTICIDAL PHENYL-OR PYRIDYL-PIPERDINE COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2013-11-28 | — | — | US | disclosed |
| US-8518971-B2 | Insecticidal phenyl- or pyridyl-piperdine compounds | SYNGENTA CROP PROTECTION, INC. (US) | 2013-08-27 | — | — | US | disclosed |
| WO-2012037282-A3 | CATALYSTS AND METHODS FOR POLYMER SYNTHESIS | NOVOMER, INC. (US) | 2012-05-10 | — | — | WO | disclosed |
| EP-2324010-B1 | INSECTICIDAL PHENYL- OR PYRIDYL-PIPERIDINE COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2011-11-30 | — | — | EP | disclosed |
| US-20110136866-A1 | INSECTICIDAL PHENYL- OR PYRIDYL-PIPERDINE COMPOUNDS | SYNGENTA CROP PROTECTION LLC (US) | 2011-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10034476-B2 | Insecticidal phenyl-or pyridyl-piperdine compounds | ACHE, CHRM1, CHRM2 | LSS 3226/4885CHRM2 3/4885CHRM3 10/4885 |
| US-20130317062-A1 | INSECTICIDAL PHENYL-OR PYRIDYL-PIPERDINE COMPOUNDS | ACHE, CHRM1, CHRM2 | LSS 3226/4885CHRM2 3/4885CHRM3 10/4885 |
| US-20110136866-A1 | INSECTICIDAL PHENYL- OR PYRIDYL-PIPERDINE COMPOUNDS | ACHE, CHRM1, CHRM2 | LSS 3190/4885CHRM2 3/4885CHRM3 9/4885 |
| US-20170347650-A1 | INSECTICIDAL PHENYL-OR PYRIDYL-PIPERDINE COMPOUNDS | ACHE, CHRM1, CHRM2 | LSS 3226/4885CHRM2 3/4885CHRM3 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.