Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.31 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL172507 | 0.85 | NFE2L2 (0.37) | TAAR1NFE2L2KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL14237093 | 0.81 | ERN1 (0.48) | TAAR1NFE2L2KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL170879 | 0.80 | TAAR1 (0.45) | TAAR1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL9310858 | 0.79 | TSHR (0.38) | KDM4EALDH1A1GAAHPGDCXCR5 | |
| SCHEMBL9310371 | 0.79 | ALDH1A1 (0.33) | KDM4EALDH1A1GAAHPGD | |
| SCHEMBL23586740 | 0.78 | NOS2 (0.33) | KDM4EALDH1A1GAAHPGD | |
| SCHEMBL9310723 | 0.78 | ALDH1A1 (0.50) | TAAR1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL9312056 | 0.78 | GABRA1 (0.38) | TAAR1KDM4EALDH1A1GAAHPGD | |
| SCHEMBL19289744 | 0.75 | GABRA1 (0.44) | TAAR1ALDH1A1HPGDF2RL1 | |
| SCHEMBL9310507 | 0.75 | TLR2 (0.39) | NFE2L2KDM4ESMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255738-B1 | GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO | NEUROCRINE BIOSCIENCES INC (US) | 2012-03-07 | — | — | EP | disclosed |