Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAK | O14976 | 1/20 | 0.43 |
| ▸ | DAGLB | Q8NCG7 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.41 |
| ▸ | DAGLA | Q9Y4D2 | 2/20 | 0.40 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17276798 | 0.88 | DAGLA (0.46) | KMT2ADAGLAALDH1A1HPGDMAPK1 | |
| SCHEMBL17276552 | 0.82 | HPGD (0.51) | KMT2AALDH1A1HPGDTSHRMAPK1 | |
| SCHEMBL17276373 | 0.81 | HPGD (0.49) | KMT2AALDH1A1HPGDTSHRMAPK1 | |
| SCHEMBL17276563 | 0.80 | HPGD (0.47) | KMT2AKDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL17276713 | 0.75 | ALDH1A1 (0.55) | KMT2AKDM4EALDH1A1SMN1; SMN2POLB | |
| SCHEMBL17276646 | 0.75 | NPC1 (0.43) | KMT2ATSHRPOLB | |
| SCHEMBL19078697 | 0.74 | CCNC (0.39) | ALDH1A1TSHR | |
| SCHEMBL17276317 | 0.73 | NPC1 (0.44) | ALDH1A1HPGDTSHRSMN1; SMN2 | |
| SCHEMBL17276663 | 0.73 | PLA2G7 (0.46) | KMT2AALDH1A1TSHRSMN1; SMN2POLB | |
| SCHEMBL19078765 | 0.72 | FAAH (0.53) | KMT2AKDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015179559-A2 | PYRAZOLE COMPOUNDS AND METHODS OF MAKING AND USING SAME | ABIDE THERAPEUTICS, INC. (US) | 2015-11-26 | — | — | WO | disclosed |