Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TGM2 | P21980 | 1/20 | 0.40 |
| ▸ | TGM1 | P22735 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17276380 | 0.95 | NOS1 (0.40) | NOS1ALDH1A1TGM2TGM1 | |
| SCHEMBL17276667 | 0.87 | NOS1 (0.43) | NOS1ALDH1A1TGM2TGM1 | |
| SCHEMBL17276502 | 0.87 | NOS1 (0.43) | NOS1ALDH1A1TGM2TGM1 | |
| SCHEMBL19078756 | 0.86 | NOS1 (0.46) | NOS1ALDH1A1TGM2TGM1 | |
| SCHEMBL15233145 | 0.85 | NOS1 (0.44) | NOS1ALDH1A1TGM2TGM1 | |
| SCHEMBL19078768 | 0.85 | NOS1 (0.44) | NOS1ALDH1A1TGM2TGM1 | |
| SCHEMBL17276475 | 0.83 | NOS1 (0.40) | NOS1ALDH1A1 | |
| SCHEMBL19078767 | 0.82 | FAAH (0.59) | ALDH1A1 | |
| SCHEMBL17276681 | 0.82 | ALDH1A1 (0.54) | ALDH1A1 | |
| SCHEMBL19078754 | 0.82 | AKR1C3 (0.49) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10093630-B2 | Pyrazole compounds and methods of making and using same | ABIDE THERAPEUTICS, INC. (US) | 2018-10-09 | — | — | US | disclosed |
| US-20170190669-A1 | PYRAZOLE COMPOUNDS AND METHODS OF MAKING AND USING SAME | H. LUNDBECK A/S (DK) | 2017-07-06 | — | — | US | disclosed |
| WO-2015179559-A2 | PYRAZOLE COMPOUNDS AND METHODS OF MAKING AND USING SAME | ABIDE THERAPEUTICS, INC. (US) | 2015-11-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170190669-A1 | PYRAZOLE COMPOUNDS AND METHODS OF MAKING AND USING SAME | ABHD6, FAAH, FAAH2 | NOS1 3558/4885ALDH1A1 1322/4885TGM2 3094/4885 |
| US-10093630-B2 | Pyrazole compounds and methods of making and using same | ABHD6, FAAH, FAAH2 | NOS1 3558/4885ALDH1A1 1322/4885TGM2 3094/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.