Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1727579 | 0.89 | SIGMAR1 (0.52) | HRH3KMT2AMAPK14MCHR1 | |
| SCHEMBL1729209 | 0.88 | DRD3 (0.56) | HRH3MAPK14MCHR1 | |
| SCHEMBL1728782 | 0.87 | HRH3 (0.46) | HRH3MAPK14MCHR1KCNH2 | |
| SCHEMBL1727513 | 0.83 | LTA4H (0.51) | HRH3ALDH1A1MAPK14MCHR1 | |
| SCHEMBL6081629 | 0.83 | HRH3 (0.47) | HRH3MAPK14MCHR1KCNH2 | |
| SCHEMBL1728829 | 0.82 | LTA4H (0.46) | HRH3MCHR1 | |
| SCHEMBL6081546 | 0.82 | HRH3 (0.42) | HRH3MAPK14MCHR1KCNH2 | |
| SCHEMBL1727559 | 0.82 | HRH3 (0.51) | HRH3KCNH2 | |
| SCHEMBL1728674 | 0.81 | ALDH1A1 (0.60) | HRH3MEN1ALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL1728856 | 0.80 | HRH3 (0.42) | HRH3MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551810-B1 | DIARYL-SUBSTITUTED CYCLIC UREA DERIVATIVES HAVING AN MCH-MODULATORY EFFECT | SANOFI AVENTIS DEUTSCHLAND (DE) | 2011-11-30 | — | — | EP | disclosed |
| US-7141561-B2 | Substituted diaryl heterocycles, process for their preparation and their use as medicaments | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-11-28 | — | — | US | disclosed |