Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 9/20 | 0.40 |
| ▸ | IMPDH1 | P20839 | 9/20 | 0.40 |
| ▸ | PDE1A | P54750 | 2/20 | 0.37 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.37 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15920699 | 0.90 | PDE1A (0.47) | IMPDH2IMPDH1PDE1APDE1BPDE3B | |
| SCHEMBL17280388 | 0.87 | NUAK1 (0.43) | IMPDH2IMPDH1KDM4ELMNAGAA | |
| SCHEMBL15920872 | 0.80 | KDM4E (0.49) | IMPDH2IMPDH1PDE1APDE1BPDE3B | |
| SCHEMBL17280356 | 0.74 | ALDH1A1 (0.47) | IMPDH2IMPDH1PDE1APDE1BPDE3B | |
| SCHEMBL17280350 | 0.72 | ALOX5 (0.52) | PDE1APDE1BPDE3BPDE1CPDE3A | |
| SCHEMBL17280382 | 0.72 | TUBB4A (0.39) | IMPDH2PDE1APDE1BPDE3BPDE1C | |
| SCHEMBL17280367 | 0.71 | KDM4E (0.47) | IMPDH2IMPDH1PDE1APDE1BPDE3B | |
| SCHEMBL17280386 | 0.71 | ALDH1A1 (0.60) | KDM4ELMNASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL17280360 | 0.70 | KDM4E (0.42) | IMPDH2IMPDH1PDE1APDE1BPDE3B | |
| SCHEMBL17280376 | 0.70 | KDM4E (0.44) | IMPDH2IMPDH1PDE1APDE1BPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9650355-B2 | Method for preparation of justicidin a derivatives of arylnaphthalene lignan structure | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2017-05-16 | — | — | US | disclosed |
| US-20150336938-A1 | METHOD FOR PREPARATION OF JUSTICIDIN A DERIVATIVES OF ARYLNAPHTHALENE LIGNAN STRUCTURE | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2015-11-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150336938-A1 | METHOD FOR PREPARATION OF JUSTICIDIN A DERIVATIVES OF ARYLNAPHTHALENE LIGNAN STRUCTURE | UGT1A8, NOTUM, MLN | IMPDH2 1236/4885IMPDH1 1196/4885PDE1A 2647/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.