Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MLYCD | O95822 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.44 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.44 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.44 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.44 |
| ▸ | AHR | P35869 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1727761 | 0.87 | KMT2A (0.41) | ALDH1A1POLBSMN1; SMN2GAAMEN1 | |
| SCHEMBL1728014 | 0.87 | NPC1 (0.45) | POLBSMN1; SMN2TP53GAAMEN1 | |
| SCHEMBL1727825 | 0.84 | RAB9A (0.52) | ALDH1A1HPGDMAPTSMN1; SMN2TP53 | |
| SCHEMBL1726839 | 0.84 | RAB9A (0.55) | ALDH1A1SMN1; SMN2TP53MEN1KMT2A | |
| SCHEMBL1727755 | 0.79 | NAMPT (0.53) | ALDH1A1POLBHPGDSMN1; SMN2MEN1 | |
| SCHEMBL1727750 | 0.78 | KMT2A (0.47) | ALDH1A1POLBMAPTTP53GAA | |
| SCHEMBL1726674 | 0.78 | NPC1 (0.52) | POLBMAPTSMN1; SMN2TP53MEN1 | |
| SCHEMBL1727814 | 0.77 | AKR1C3 (0.46) | ALDH1A1MAPTGAAMEN1KMT2A | |
| SCHEMBL1727700 | 0.77 | KMT2A (0.50) | ALDH1A1POLBMAPTSMN1; SMN2TP53 | |
| SCHEMBL1728219 | 0.77 | NAMPT (0.49) | POLBMEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403499-A2 | METHODS AND COMPOSITIONS USEFUL IN TREATING CANCER AND REDUCING WNT MEDIATED EFFECTS IN A CELL | Stemsynergy Therapeutics, Inc (US) | 2012-01-11 | — | — | EP | disclosed |
| WO-2010101964-A2 | METHODS AND COMPOSITIONS USEFUL IN TREATING CANCER AND REDUCING WNT MEDIATED EFFECTS IN A CELL | STEMSYNERGY THERAPEUTICS, INC (US) | 2010-09-10 | — | — | WO | disclosed |