Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | CXCR2 | P25025 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1726674 | 0.80 | NPC1 (0.52) | RAB9ANPC1KMT2AMEN1POLB | |
| SCHEMBL1727755 | 0.79 | NAMPT (0.53) | NAMPTRAB9AKDM4EHTTKMT2A | |
| SCHEMBL1728014 | 0.79 | NPC1 (0.45) | NAMPTRAB9ANPC1HTTKMT2A | |
| SCHEMBL1727677 | 0.79 | NAMPT (0.55) | NAMPTRAB9ANPC1KDM4EKMT2A | |
| SCHEMBL1728035 | 0.78 | RAB9A (0.52) | RAB9ANPC1KMT2AMEN1 | |
| SCHEMBL1727944 | 0.78 | LRRK2 (0.59) | RAB9ANPC1KDM4EHTTKMT2A | |
| SCHEMBL1727761 | 0.77 | KMT2A (0.41) | NAMPTKDM4EKMT2AMEN1POLB | |
| SCHEMBL1728187 | 0.77 | ALDH1A1 (0.53) | RAB9ANPC1KDM4EHTTKMT2A | |
| SCHEMBL1727814 | 0.76 | AKR1C3 (0.46) | CYP1A2KMT2AMEN1 | |
| SCHEMBL1727700 | 0.76 | KMT2A (0.50) | RAB9ANPC1HTTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403499-A2 | METHODS AND COMPOSITIONS USEFUL IN TREATING CANCER AND REDUCING WNT MEDIATED EFFECTS IN A CELL | Stemsynergy Therapeutics, Inc (US) | 2012-01-11 | — | — | EP | disclosed |
| WO-2010101964-A2 | METHODS AND COMPOSITIONS USEFUL IN TREATING CANCER AND REDUCING WNT MEDIATED EFFECTS IN A CELL | STEMSYNERGY THERAPEUTICS, INC (US) | 2010-09-10 | — | — | WO | disclosed |