Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.52 |
| ▸ | RAB9A | P51151 | 5/20 | 0.52 |
| ▸ | GRM5 | P41594 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1727761 | 0.80 | KMT2A (0.41) | KMT2ASMN1; SMN2MEN1LMNAPOLB | |
| SCHEMBL1727755 | 0.80 | NAMPT (0.53) | RAB9AKMT2ASMN1; SMN2MEN1LMNA | |
| SCHEMBL1728219 | 0.80 | NAMPT (0.49) | NPC1RAB9AKMT2AMEN1POLB | |
| SCHEMBL1728014 | 0.80 | NPC1 (0.45) | NPC1RAB9AKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL1727750 | 0.80 | KMT2A (0.47) | NPC1RAB9AKMT2AMEN1RXFP1 | |
| SCHEMBL1726609 | 0.79 | MAPT (0.54) | NPC1RAB9AKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL1727700 | 0.78 | KMT2A (0.50) | NPC1RAB9AKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL1728196 | 0.78 | LMNA (0.50) | NPC1RAB9AKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL1727751 | 0.78 | PARP1 (0.43) | KMT2AMEN1RXFP1MAPTPOLB | |
| SCHEMBL1727825 | 0.78 | RAB9A (0.52) | NPC1RAB9AKMT2ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403499-A2 | METHODS AND COMPOSITIONS USEFUL IN TREATING CANCER AND REDUCING WNT MEDIATED EFFECTS IN A CELL | Stemsynergy Therapeutics, Inc (US) | 2012-01-11 | — | — | EP | disclosed |
| WO-2010101964-A2 | METHODS AND COMPOSITIONS USEFUL IN TREATING CANCER AND REDUCING WNT MEDIATED EFFECTS IN A CELL | STEMSYNERGY THERAPEUTICS, INC (US) | 2010-09-10 | — | — | WO | disclosed |