Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 5/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMO | Q99835 | 1/20 | 0.32 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HTR3B | O95264 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1729611 | 0.87 | HTR1A (0.39) | HTR3ALMNAHTT | |
| SCHEMBL1729592 | 0.86 | PTGES (0.42) | PTGESPDE10AFAAHPDE4APDE4B | |
| SCHEMBL1727957 | 0.85 | KDM4E (0.45) | PDE10AHTR3ALMNAHTTHTR3E | |
| SCHEMBL1730418 | 0.82 | HRH3 (0.45) | PDE10AHTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL1727545 | 0.82 | GRIN2D (0.36) | HTR3AHTR3EMEN1HTR3BCYP1A2 | |
| SCHEMBL1727926 | 0.81 | HRH3 (0.46) | PDE10AHTR3ALMNAHTR3EHTR3B | |
| SCHEMBL1727570 | 0.80 | CNR1 (0.39) | — | |
| SCHEMBL1730161 | 0.80 | DEGS1 (0.43) | PDE10A | |
| SCHEMBL1730251 | 0.78 | DPP4 (0.42) | HTR3A | |
| SCHEMBL1729774 | 0.77 | LMNA (0.36) | GAALMNAHTTMEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633735-B1 | DERIVATIVES OF PIPERIDINYL- AND PIPERAZINYL-ALKYL CARBAMATES, PREPARATION METHODS THEREOF AND APPLICATION OF SAME IN THERAPEUTICS | SANOFI SA (FR) | 2011-11-30 | — | — | EP | claimed |