Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 7/20 | 0.63 |
| ▸ | KDM4A | O75164 | 4/20 | 0.56 |
| ▸ | KDM4B | O94953 | 4/20 | 0.56 |
| ▸ | KDM5B | Q9UGL1 | 4/20 | 0.56 |
| ▸ | KDM5C | P41229 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1726833 | 0.89 | KDM4A (0.60) | ADORA3KDM4AKDM4BKDM5BKDM5C | |
| SCHEMBL1728489 | 0.83 | KDM4A (0.62) | ADORA3KDM4AKDM4BKDM5BKDM5C | |
| SCHEMBL1726474 | 0.79 | L3MBTL1 (0.53) | ADORA3KDM4AKDM4BKDM5BKDM5C | |
| SCHEMBL1726841 | 0.79 | PHGDH (0.60) | MAPTLMNASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL1728020 | 0.78 | KMT2A (0.60) | ADORA3USP2MAPTLMNASMN1; SMN2 | |
| SCHEMBL662890 | 0.77 | ADORA3 (0.63) | ADORA3KDM4AKDM4BKDM5BKDM5C | |
| SCHEMBL665571 | 0.76 | ADORA3 (0.78) | ADORA3KDM4AKDM4BKDM5BKDM5C | |
| SCHEMBL1728487 | 0.76 | MEN1 (0.51) | MAPK1MAPTLMNASMN1; SMN2KDM4E | |
| SCHEMBL18997294 | 0.75 | ADORA3 (0.80) | ADORA3KDM4AKDM4BKDM5BKDM5C | |
| SCHEMBL29978560 | 0.75 | ADORA3 (0.75) | ADORA3KDM4AKDM4BKDM5BKDM5C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403499-A2 | METHODS AND COMPOSITIONS USEFUL IN TREATING CANCER AND REDUCING WNT MEDIATED EFFECTS IN A CELL | Stemsynergy Therapeutics, Inc (US) | 2012-01-11 | — | — | EP | disclosed |
| WO-2010101964-A2 | METHODS AND COMPOSITIONS USEFUL IN TREATING CANCER AND REDUCING WNT MEDIATED EFFECTS IN A CELL | STEMSYNERGY THERAPEUTICS, INC (US) | 2010-09-10 | — | — | WO | disclosed |