Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 10/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | SCD | O00767 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | PPARG | P37231 | 1/20 | 0.53 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.53 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.53 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.53 |
| ▸ | ESR1 | P03372 | 1/20 | 0.53 |
| ▸ | NAMPT | P43490 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1728020 | 0.93 | KMT2A (0.60) | PHGDHSMN1; SMN2KDM4EMEN1ALDH1A1 | |
| SCHEMBL1728487 | 0.91 | MEN1 (0.51) | PHGDHSMN1; SMN2KDM4EMEN1ALDH1A1 | |
| SCHEMBL1726833 | 0.90 | KDM4A (0.60) | SMN1; SMN2KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL1727760 | 0.85 | MEN1 (0.44) | PHGDHSMN1; SMN2KDM4EMEN1ALDH1A1 | |
| SCHEMBL1728196 | 0.82 | LMNA (0.50) | SMN1; SMN2KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL1728489 | 0.82 | KDM4A (0.62) | SMN1; SMN2KDM4EMAPTLMNANCOA1 | |
| SCHEMBL1728185 | 0.82 | MAPT (0.55) | SMN1; SMN2SCDKDM4EMEN1ALDH1A1 | |
| SCHEMBL1728252 | 0.79 | ADORA3 (0.63) | SMN1; SMN2KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL1726474 | 0.78 | L3MBTL1 (0.53) | SMN1; SMN2ALDH1A1LMNANCOA1 | |
| SCHEMBL1727755 | 0.77 | NAMPT (0.53) | SMN1; SMN2KDM4EMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403499-A2 | METHODS AND COMPOSITIONS USEFUL IN TREATING CANCER AND REDUCING WNT MEDIATED EFFECTS IN A CELL | Stemsynergy Therapeutics, Inc (US) | 2012-01-11 | — | — | EP | disclosed |
| WO-2010101964-A2 | METHODS AND COMPOSITIONS USEFUL IN TREATING CANCER AND REDUCING WNT MEDIATED EFFECTS IN A CELL | STEMSYNERGY THERAPEUTICS, INC (US) | 2010-09-10 | — | — | WO | disclosed |