Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.51 |
| ▸ | MAPT | P10636 | 7/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | PHGDH | O43175 | 8/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.48 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.48 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1728020 | 0.91 | KMT2A (0.60) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL1726841 | 0.91 | PHGDH (0.60) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL1726833 | 0.84 | KDM4A (0.60) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL1727760 | 0.81 | MEN1 (0.44) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL1727750 | 0.79 | KMT2A (0.47) | MEN1KMT2AMAPTALDH1A1GAA | |
| SCHEMBL1727761 | 0.78 | KMT2A (0.41) | MEN1KMT2AALDH1A1KDM4EGAA | |
| SCHEMBL1728489 | 0.77 | KDM4A (0.62) | MAPTKDM4ESMN1; SMN2TDP1LMNA | |
| SCHEMBL1728185 | 0.77 | MAPT (0.55) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL16607135 | 0.77 | ALDH1A1 (0.76) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL1727755 | 0.76 | NAMPT (0.53) | MEN1KMT2AALDH1A1KDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403499-A2 | METHODS AND COMPOSITIONS USEFUL IN TREATING CANCER AND REDUCING WNT MEDIATED EFFECTS IN A CELL | Stemsynergy Therapeutics, Inc (US) | 2012-01-11 | — | — | EP | disclosed |
| WO-2010101964-A2 | METHODS AND COMPOSITIONS USEFUL IN TREATING CANCER AND REDUCING WNT MEDIATED EFFECTS IN A CELL | STEMSYNERGY THERAPEUTICS, INC (US) | 2010-09-10 | — | — | WO | disclosed |