Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 7/20 | 0.55 |
| ▸ | NPC1 | O15118 | 6/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | SCD | O00767 | 7/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | MMP13 | P45452 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
| ▸ | TOP1 | P11387 | 1/20 | 0.47 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1727655 | 0.90 | SMN1; SMN2 (0.59) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL1727944 | 0.90 | LRRK2 (0.59) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL1726609 | 0.87 | MAPT (0.54) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL1728196 | 0.82 | LMNA (0.50) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL1726841 | 0.82 | PHGDH (0.60) | MAPTMEN1KMT2ASMN1; SMN2SCD | |
| SCHEMBL1727649 | 0.81 | MEN1 (0.60) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL1726833 | 0.80 | KDM4A (0.60) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL1728020 | 0.79 | KMT2A (0.60) | MAPTMEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL1727755 | 0.79 | NAMPT (0.53) | RAB9AMEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL1728014 | 0.78 | NPC1 (0.45) | RAB9ANPC1MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403499-A2 | METHODS AND COMPOSITIONS USEFUL IN TREATING CANCER AND REDUCING WNT MEDIATED EFFECTS IN A CELL | Stemsynergy Therapeutics, Inc (US) | 2012-01-11 | — | — | EP | disclosed |
| WO-2010101964-A2 | METHODS AND COMPOSITIONS USEFUL IN TREATING CANCER AND REDUCING WNT MEDIATED EFFECTS IN A CELL | STEMSYNERGY THERAPEUTICS, INC (US) | 2010-09-10 | — | — | WO | disclosed |