Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.52 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 3/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.42 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.42 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1727854 | 0.89 | LTA4H (0.52) | LTA4HMCHR1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1728669 | 0.88 | LTA4H (0.68) | LTA4HMCHR1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1728647 | 0.88 | KDM4E (0.55) | LTA4HMCHR1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1728764 | 0.86 | GALR3 (0.52) | LTA4HMCHR1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1729490 | 0.83 | MAPK14 (0.56) | LTA4HMCHR1ALDH1A1FGFR1MAPK14 | |
| SCHEMBL1728643 | 0.83 | MCHR1 (0.52) | LTA4HMCHR1ALDH1A1FGFR1MAPK14 | |
| SCHEMBL1728527 | 0.82 | MCHR1 (0.51) | LTA4HMCHR1FGFR1MAPK14CYP1A2 | |
| SCHEMBL1727319 | 0.82 | LTA4H (0.51) | LTA4HMCHR1KDM4ESMN1; SMN2ESR1 | |
| SCHEMBL1728773 | 0.81 | CHRNB2 (0.59) | LTA4HMCHR1FGFR1MAPK14CYP1A2 | |
| SCHEMBL6081331 | 0.80 | MCHR1 (0.53) | LTA4HMCHR1SMN1; SMN2ESR1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551810-B1 | DIARYL-SUBSTITUTED CYCLIC UREA DERIVATIVES HAVING AN MCH-MODULATORY EFFECT | SANOFI AVENTIS DEUTSCHLAND (DE) | 2011-11-30 | — | — | EP | disclosed |
| US-7141561-B2 | Substituted diaryl heterocycles, process for their preparation and their use as medicaments | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-11-28 | — | — | US | disclosed |