Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GALR3 | O60755 | 4/20 | 0.52 |
| ▸ | LTA4H | P09960 | 2/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CACNA1B | Q00975 | 5/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1727854 | 0.86 | LTA4H (0.52) | LTA4HMCHR1KDM4EALDH1A1CACNA1B | |
| SCHEMBL1728528 | 0.86 | LTA4H (0.52) | LTA4HMCHR1KDM4EALDH1A1CACNA1B | |
| SCHEMBL1728669 | 0.85 | LTA4H (0.68) | LTA4HMCHR1KDM4EALDH1A1CACNA1B | |
| SCHEMBL1728647 | 0.85 | KDM4E (0.55) | LTA4HMCHR1KDM4EALDH1A1CACNA1B | |
| SCHEMBL1727319 | 0.82 | LTA4H (0.51) | LTA4HMCHR1KDM4ECACNA1BCACNA1H | |
| SCHEMBL1729490 | 0.81 | MAPK14 (0.56) | LTA4HMCHR1ALDH1A1 | |
| SCHEMBL6081954 | 0.78 | MCHR1 (0.49) | GALR3LTA4HMCHR1KDM4EALDH1A1 | |
| SCHEMBL1728773 | 0.78 | CHRNB2 (0.59) | LTA4HMCHR1 | |
| SCHEMBL1728527 | 0.78 | MCHR1 (0.51) | LTA4HMCHR1 | |
| SCHEMBL1728628 | 0.77 | MCHR1 (0.51) | LTA4HMCHR1KDM4ECACNA1BCACNA1H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551810-B1 | DIARYL-SUBSTITUTED CYCLIC UREA DERIVATIVES HAVING AN MCH-MODULATORY EFFECT | SANOFI AVENTIS DEUTSCHLAND (DE) | 2011-11-30 | — | — | EP | disclosed |
| US-7141561-B2 | Substituted diaryl heterocycles, process for their preparation and their use as medicaments | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-11-28 | — | — | US | disclosed |