Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | LTA4H | P09960 | 1/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.50 |
| ▸ | CSF1R | P07333 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1728528 | 0.88 | LTA4H (0.52) | KDM4ELTA4HMCHR1CSF1RALDH1A1 | |
| SCHEMBL1727854 | 0.88 | LTA4H (0.52) | KDM4ELTA4HMCHR1CSF1RALDH1A1 | |
| SCHEMBL1728669 | 0.87 | LTA4H (0.68) | KDM4ELTA4HMCHR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL1728764 | 0.85 | GALR3 (0.52) | KDM4ELTA4HMCHR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL1729490 | 0.82 | MAPK14 (0.56) | LTA4HMCHR1ALDH1A1MAPK14CYP1A2 | |
| SCHEMBL1727319 | 0.81 | LTA4H (0.51) | KDM4ELTA4HMCHR1SMN1; SMN2MAPK14 | |
| SCHEMBL1729494 | 0.81 | MCHR1 (0.51) | LTA4HMCHR1MAPTMAPK14CYP1A2 | |
| SCHEMBL1728773 | 0.80 | CHRNB2 (0.59) | LTA4HMCHR1CSF1RMAPK14CYP1A2 | |
| SCHEMBL1728527 | 0.79 | MCHR1 (0.51) | LTA4HMCHR1MAPK14CYP1A2CYP2D6 | |
| SCHEMBL6081522 | 0.78 | ALDH1A1 (0.55) | KDM4ELTA4HMCHR1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551810-B1 | DIARYL-SUBSTITUTED CYCLIC UREA DERIVATIVES HAVING AN MCH-MODULATORY EFFECT | SANOFI AVENTIS DEUTSCHLAND (DE) | 2011-11-30 | — | — | EP | disclosed |
| US-7141561-B2 | Substituted diaryl heterocycles, process for their preparation and their use as medicaments | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-11-28 | — | — | US | disclosed |