Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 4/20 | 0.58 |
| ▸ | HRH2 | P25021 | 7/20 | 0.43 |
| ▸ | HRH1 | P35367 | 7/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MC4R | P32245 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1729481 | 0.86 | LTA4H (0.67) | LTA4HHRH2HRH1HTR7KDM1A | |
| SCHEMBL1727513 | 0.84 | LTA4H (0.51) | LTA4HHRH2HRH1HRH3KDM4E | |
| SCHEMBL1729209 | 0.82 | DRD3 (0.56) | HRH3KDM1A | |
| SCHEMBL1728782 | 0.81 | HRH3 (0.46) | LTA4HHRH2HRH1HRH3 | |
| SCHEMBL1727579 | 0.81 | SIGMAR1 (0.52) | HRH3KDM4E | |
| SCHEMBL6081629 | 0.81 | HRH3 (0.47) | HRH2HRH1HRH3KDM1AKDM4E | |
| SCHEMBL1727689 | 0.80 | HRH3 (0.48) | HRH3ALDH1A1 | |
| SCHEMBL14446227 | 0.77 | HRH3 (0.47) | HRH3ACACB | |
| SCHEMBL1728829 | 0.75 | LTA4H (0.46) | LTA4HHRH2HRH1HRH3 | |
| SCHEMBL1728644 | 0.75 | HRH3 (0.42) | HRH3ACACBKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551810-B1 | DIARYL-SUBSTITUTED CYCLIC UREA DERIVATIVES HAVING AN MCH-MODULATORY EFFECT | SANOFI AVENTIS DEUTSCHLAND (DE) | 2011-11-30 | — | — | EP | disclosed |
| US-7141561-B2 | Substituted diaryl heterocycles, process for their preparation and their use as medicaments | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-11-28 | — | — | US | disclosed |