SCHEMBL1729178

SCHEMBL1729178

O=S(=O)(Nc1ccccc1)Oc1ccccc1

nearest known ligand 0.53

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.53
MEN1 O00255 2/20 0.53
CA1 P00915 5/20 0.50
CA2 P00918 5/20 0.50
CA9 Q16790 4/20 0.50
KEAP1 Q14145 2/20 0.50
SLC40A1 Q9NP59 1/20 0.49
PGR P06401 5/20 0.48
IL1RN P18510 1/20 0.48
ERAP1 Q9NZ08 1/20 0.48
ALDH1A1 P00352 1/20 0.45
PKM P14618 1/20 0.45
HPGD P15428 1/20 0.44
HTT P42858 1/20 0.44
CA12 O43570 2/20 0.43
LMNA P02545 1/20 0.41
PPARG P37231 1/20 0.41
NFE2L2 Q16236 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10325170 0.98 KMT2A (0.52) KMT2AMEN1CA1CA2CA9
SCHEMBL8762798 0.88 CA2 (0.56) KMT2AMEN1CA1CA2CA9
SCHEMBL28166872 0.87 KEAP1 (0.56) KMT2AMEN1CA1CA2CA9
SCHEMBL14582134 0.82 NPSR1 (0.49) KMT2AMEN1SLC40A1ALDH1A1HPGD
SCHEMBL3673727 0.81 SMN1; SMN2 (0.60) KMT2AMEN1CA1CA2CA9
SCHEMBL3683057 0.81 GAA (0.60) KMT2AMEN1CA1CA2CA9
SCHEMBL2016598 0.79 KEAP1 (0.56) KMT2AMEN1CA1CA2CA9
SCHEMBL10736241 0.76 KMT2A (0.60) KMT2AMEN1CA1CA2CA9
SCHEMBL20768536 0.76 KMT2A (0.60) KMT2AMEN1CA1CA2CA9
SCHEMBL4805555 0.76 KMT2A (0.55) KMT2AMEN1CA1CA2CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060252645-A1 Method for producing material containing sensitizer dispersed therein for thermal recording article an thermal recording article SANKO CO., LTD. (JP) 2006-11-09 US claimed
EP-1645430-A1 METHOD FOR PRODUCING MATERIAL CONTAINING SENSITIZER DISPERSED THEREIN FOR THERMAL RECORDING ARTICLE AND THERMAL RECORDING ARTICLE Sanko Co., Ltd. (JP) 2006-04-12 EP claimed
CN-1738928-A Compositions for copper, tantalum and tantalum nitride chemical mechanical method complanation HONEYWELL INT INC (US) 2006-02-22 CN claimed
CN-1382305-A Compositions and methods for spin etch planarization ALLIED SIGNAL INC (US) 2002-11-27 CN claimed
CN-106222752-B A method of preparing organic crystal film 上海理工大学 2019-02-15 CN disclosed
EP-2889149-B1 SENSITIZER PARTICLE DISPERSION FOR THERMOSENSITIVE RECORDING MEDIUM COMPOSED MAINLY OF STEARIC ACID AMIDE, PREPARATION METHOD THEREOF, MIXED DISPERSION COMPOSITION FOR THERMOSENSITIVE RECORDING LAYER, AND THERMOSENSITIVE RECORDING MEDIUM SANKO CO LTD (JP) 2017-01-04 EP disclosed
US-9375966-B2 Sensitizer particle dispersion for thermosensitive recording medium composed mainly of stearic acid amide, preparation method thereof, mixed dispersion composition for thermosensitive recording layer, and thermosensitive recording medium SANKO CO., LTD. (JP) 2016-06-28 US disclosed
US-20150183252-A1 SENSITIZER PARTICLE DISPERSION FOR THERMOSENSITIVE RECORDING MEDIUM COMPOSED MAINLY OF STEARIC ACID AMIDE, PREPARATION METHOD THEREOF, MIXED DISPERSION COMPOSITION FOR THERMOSENSITIVE RECORDING LAYER, AND THERMOSENSITIVE RECORDING MEDIUM SANKO CO., LTD. (JP) 2015-07-02 US disclosed
EP-2889149-A1 SENSITIZER PARTICLE DISPERSION FOR THERMOSENSITIVE RECORDING MEDIUM COMPOSED MAINLY OF STEARIC ACID AMIDE, PREPARATION METHOD THEREOF, MIXED DISPERSION COMPOSITION FOR THERMOSENSITIVE RECORDING LAYER, AND THERMOSENSITIVE RECORDING MEDIUM Sanko Co., Ltd. (JP) 2015-07-01 EP disclosed
EP-1645430-B1 METHOD FOR PRODUCING MATERIAL CONTAINING SENSITIZER DISPERSED THEREIN FOR HEAT-SENSITIVE RECORDING MATERIAL SANKO CO LTD (JP) 2011-11-30 EP disclosed
EP-1431293-B1 WATER-SOLUBLE PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME KOWA CO (JP) 2011-06-08 EP disclosed
US-20090270399-A1 NOVEL PYRIDAZINE DERIVATIVES AND MEDICINES CONTAINING THE SAME AS EFFECTIVE INGREDIENTS KOWA CO., LTD. (JP) 2009-10-29 US disclosed
CN-1341103-A Pyridazin-3-one derivatives and drugs containing the same KOWA CO (JP) 2002-03-20 CN disclosed
US-6348468-B1 THESE COMPOUNDS HAVE EXCELLENT INHIBITORY ACTIVITY AGAINST INTERLEUKIN-1.BETA. PRODUCTION, IMMUNE SYSTEM DISEASES, INFLAMMATORY DISEASES, ISCHEMIC DISEASES AND THE LIKE. KOWA CO., LTD. (JP) 2002-02-19 US disclosed
EP-1156039-A1 PYRIDAZIN-3-ONE DERIVATIVES AND MEDICINES CONTAINING THE SAME Kowa Co., Ltd. (JP) 2001-11-21 EP disclosed
EP-1061077-A1 NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT Kowa Co., Ltd. (JP) 2000-12-20 EP disclosed
EP-1043317-A1 NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT Kowa Co., Ltd. (JP) 2000-10-11 EP disclosed
EP-0427929-A2 Heat-sensitive recording material MITSUBISHI PAPER MILLS, LTD. (JP) 1991-05-22 EP disclosed
EP-0032625-A2 Water-soluble monoazo dyes IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1981-07-29 EP disclosed
US-3957553-A CHELATE COMPOUNDS, OXIDIZERS, 1A HYDROXIDES PENNWALT CORPORATION (US) 1976-05-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090270399-A1 NOVEL PYRIDAZINE DERIVATIVES AND MEDICINES CONTAINING THE SAME AS EFFECTIVE INGREDIENTS IL1B, IL1R1, TLR1 KMT2A 3265/4885MEN1 4730/4885CA1 4799/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.