Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 7/20 | 0.39 |
| ▸ | MMP9 | P14780 | 7/20 | 0.39 |
| ▸ | MMP3 | P08254 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MMP13 | P45452 | 6/20 | 0.38 |
| ▸ | MMP8 | P22894 | 5/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17294193 | 0.94 | MMP2 (0.45) | MMP2MMP9MMP3LMNAMMP13 | |
| SCHEMBL17294150 | 0.88 | LMNA (0.41) | MMP2MMP9MMP3LMNAMMP13 | |
| SCHEMBL17294138 | 0.79 | LMNA (0.50) | MMP2MMP9MMP3LMNAMMP8 | |
| SCHEMBL472546 | 0.79 | LMNA (0.44) | MMP2MMP9MMP3LMNAMMP13 | |
| SCHEMBL17294166 | 0.79 | TP53 (0.31) | TP53 | |
| SCHEMBL17294188 | 0.76 | TP53 (0.34) | MMP2MMP9LMNAMMP8TP53 | |
| SCHEMBL17294153 | 0.76 | LMNA (0.40) | MMP2MMP9LMNAMMP13MMP8 | |
| SCHEMBL17294175 | 0.74 | ALOX15 (0.33) | — | |
| SCHEMBL17294158 | 0.73 | TP53 (0.35) | MMP2MMP9LMNAMMP8TP53 | |
| SCHEMBL1683293 | 0.73 | LMNA (0.58) | MMP2MMP9MMP3LMNAMMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3148983-A1 | N-HYDROXYLAMINO-BARBITURIC ACID DERIVATIVES AS NITROXYL DONORS | The Johns Hopkins University (US) | 2017-04-05 | — | — | EP | claimed |
| WO-2015183838-A1 | N-HYDROXYLAMINO-BARBITURIC ACID DERIVATIVES AS NITROXYL DONORS | THE JOHNS HOPKINS UNIVERSITY (US) | 2015-12-03 | — | — | WO | claimed |
| EP-3148983-A1 | N-HYDROXYLAMINO-BARBITURIC ACID DERIVATIVES AS NITROXYL DONORS | The Johns Hopkins University (US) | 2017-04-05 | — | — | EP | disclosed |
| WO-2015183838-A1 | N-HYDROXYLAMINO-BARBITURIC ACID DERIVATIVES AS NITROXYL DONORS | THE JOHNS HOPKINS UNIVERSITY (US) | 2015-12-03 | — | — | WO | disclosed |