Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.42 |
| ▸ | GABRR2 | P28476 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | QPCT | Q16769 | 1/20 | 0.40 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17294152 | 0.72 | ATM (0.47) | ALDH1A1CYP3A4TSHRKDM4ELMNA | |
| SCHEMBL17294164 | 0.67 | MMP2 (0.43) | ALDH1A1KDM4EPOLBRECQLMAPT | |
| SCHEMBL17294173 | 0.66 | ADAM17 (0.47) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL17294138 | 0.65 | LMNA (0.50) | ALDH1A1CYP3A4GABRB2KDM4ELMNA | |
| SCHEMBL17294161 | 0.64 | DNMT1 (0.39) | PKMALDH1A1POLBRECQLMAPT | |
| SCHEMBL17294151 | 0.62 | TP53 (0.41) | ALDH1A1LMNA | |
| SCHEMBL29419502 | 0.62 | TSHR (0.49) | PKMALDH1A1CYP3A4TSHRGABRA1 | |
| SCHEMBL17294188 | 0.62 | TP53 (0.34) | LMNA | |
| SCHEMBL1268284 | 0.62 | — | — | |
| SCHEMBL8818280 | 0.61 | CYP3A4 (0.73) | PKMALDH1A1CYP3A4TSHRGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3148983-A1 | N-HYDROXYLAMINO-BARBITURIC ACID DERIVATIVES AS NITROXYL DONORS | The Johns Hopkins University (US) | 2017-04-05 | — | — | EP | claimed |
| US-9464061-B2 | N-hydroxylamino-barbituric acid derivatives | THE JOHNS HOPKINS UNIVERSITY (US) | 2016-10-11 | — | — | US | claimed |
| US-20160060229-A1 | N-HYDROXYLAMINO-BARBITURIC ACID DERIVATIVES | NATIONAL SCIENCE FOUNDATION | 2016-03-03 | — | — | US | claimed |
| WO-2015183838-A1 | N-HYDROXYLAMINO-BARBITURIC ACID DERIVATIVES AS NITROXYL DONORS | THE JOHNS HOPKINS UNIVERSITY (US) | 2015-12-03 | — | — | WO | claimed |
| EP-3148983-A1 | N-HYDROXYLAMINO-BARBITURIC ACID DERIVATIVES AS NITROXYL DONORS | The Johns Hopkins University (US) | 2017-04-05 | — | — | EP | disclosed |
| US-9464061-B2 | N-hydroxylamino-barbituric acid derivatives | THE JOHNS HOPKINS UNIVERSITY (US) | 2016-10-11 | — | — | US | disclosed |
| US-9464061-B2 | N-hydroxylamino-barbituric acid derivatives | THE JOHNS HOPKINS UNIVERSITY (US) | 2016-10-11 | — | — | US | disclosed |
| US-20160060229-A1 | N-HYDROXYLAMINO-BARBITURIC ACID DERIVATIVES | NATIONAL SCIENCE FOUNDATION | 2016-03-03 | — | — | US | disclosed |
| US-20160060229-A1 | N-HYDROXYLAMINO-BARBITURIC ACID DERIVATIVES | NATIONAL SCIENCE FOUNDATION | 2016-03-03 | — | — | US | disclosed |
| WO-2015183838-A1 | N-HYDROXYLAMINO-BARBITURIC ACID DERIVATIVES AS NITROXYL DONORS | THE JOHNS HOPKINS UNIVERSITY (US) | 2015-12-03 | — | — | WO | disclosed |
| WO-2015183838-A1 | N-HYDROXYLAMINO-BARBITURIC ACID DERIVATIVES AS NITROXYL DONORS | THE JOHNS HOPKINS UNIVERSITY (US) | 2015-12-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160060229-A1 | N-HYDROXYLAMINO-BARBITURIC ACID DERIVATIVES | TNNT2, TNNI3, TNNC1 | PKM 2162/4885ALDH1A1 654/4885CYP3A4 839/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.