Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 4/20 | 0.38 |
| ▸ | NOS1 | P29475 | 4/20 | 0.38 |
| ▸ | NOS2 | P35228 | 4/20 | 0.38 |
| ▸ | FABP6 | P51161 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TERT | O14746 | 1/20 | 0.32 |
| ▸ | NQO1 | P15559 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7123821 | 0.81 | NOS3 (0.38) | NOS3NOS1NOS2KDM4ETERT | |
| SCHEMBL17299129 | 0.75 | NQO1 (0.33) | NQO1 | |
| SCHEMBL3220307 | 0.73 | NOS3 (0.48) | NOS3NOS1NOS2FABP6ALDH1A1 | |
| SCHEMBL14108680 | 0.71 | NOS3 (0.39) | NOS3NOS1NOS2ALDH1A1SMN1; SMN2 | |
| SCHEMBL20455590 | 0.68 | ALDH1A1 (0.34) | NOS3NOS1NOS2ALDH1A1CYP3A4 | |
| SCHEMBL31453144 | 0.68 | TDP1 (0.39) | NOS3NOS1NOS2CYP3A4TSHR | |
| SCHEMBL28292898 | 0.67 | NOS3 (0.44) | NOS3NOS1NOS2ALDH1A1CYP3A4 | |
| SCHEMBL9753602 | 0.67 | NOS3 (0.44) | NOS3NOS1NOS2ALDH1A1CYP3A4 | |
| SCHEMBL26650656 | 0.66 | PRNP (0.35) | NOS3NOS1NOS2ALDH1A1TERT | |
| SCHEMBL27454384 | 0.65 | CYP3A4 (0.43) | NOS3NOS1NOS2ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9655965-B2 | Radiosensitizer compounds for use in combination with radiation | Lu qing-bin (CA) | 2017-05-23 | — | — | US | disclosed |
| US-20160235743-A1 | NON-PLATINUM-BASED ANTI-CANCER COMPOUNDS FOR USE IN TARGETED CHEMOTHERAPY | Lu qing-bin (CA) | 2016-08-18 | — | — | US | disclosed |
| US-20150343059-A1 | RADIOSENSITIZER COMPOUNDS FOR USE IN COMBINATION WITH RADIATION | Lu qing-bin (CA) | 2015-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150343059-A1 | RADIOSENSITIZER COMPOUNDS FOR USE IN COMBINATION WITH RADIATION | RB1, ERCC2, RBBP7 | NOS3 3412/4885NOS1 3176/4885NOS2 3139/4885 |
| US-20160235743-A1 | NON-PLATINUM-BASED ANTI-CANCER COMPOUNDS FOR USE IN TARGETED CHEMOTHERAPY | TOP2B, POLR2B, RB1 | NOS3 2413/4885NOS1 1975/4885NOS2 2247/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.