Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 6/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 2/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7677679 | 0.78 | FFAR2 (0.46) | HSD17B10HDAC4HDAC7HDAC5FFAR2 | |
| SCHEMBL20811278 | 0.78 | FFAR2 (0.46) | HSD17B10HDAC4HDAC7HDAC5FFAR2 | |
| SCHEMBL7677677 | 0.78 | FFAR2 (0.46) | HSD17B10HDAC4HDAC7HDAC5FFAR2 | |
| SCHEMBL4480601 | 0.77 | HDAC3 (0.41) | HDAC4HDAC7HDAC5LMNACHRM1 | |
| SCHEMBL7042356 | 0.77 | ESR1 (0.41) | HSD17B10TSHRHIF1ATDP1MEN1 | |
| SCHEMBL2074728 | 0.76 | EPHX1 (0.48) | HDAC4HDAC7HDAC5TSHRMEN1 | |
| SCHEMBL4481760 | 0.71 | ALDH1A1 (0.43) | MEN1KMT2ALMNAHPGDSLC6A4 | |
| SCHEMBL10979443 | 0.71 | ALDH1A1 (0.42) | TSHRMAPK1TDP1MEN1KMT2A | |
| SCHEMBL1792519 | 0.69 | HSD17B10 (0.46) | HSD17B10HDAC4HDAC7HDAC5FFAR2 | |
| SCHEMBL1978297 | 0.69 | HSD17B10 (0.46) | HSD17B10HDAC4HDAC7HDAC5FFAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8071788-B2 | Method and intermediates for the preparation of derivatives of N-(1-benzhydrylazetidin-3-yl)-N-phenylmethylsulfonamide | SANOFI-AVENTIS (FR) | 2011-12-06 | — | — | US | claimed |
| EP-1802571-B1 | METHOD AND INTERMEDIATES FOR THE PREPARATION OF DERIVATIVES OF N-(1-BENZHYDRYL-AZETIDIN-3-YL)-N-PHENYL-METHYLSULPHONAMIDE | AVENTIS PHARMA SA (FR) | 2011-11-23 | — | — | EP | claimed |
| US-20100087414-A1 | METHOD AND INTERMEDIATES FOR THE PREPARATION OF DERIVATIVES OF N (1-BENZHYDRYLAZETIDIN-3-YL)-N-PHENYLMETHYLSULFONAMIDE | SANOFI-AVENTIS (FR) | 2010-04-08 | — | — | US | claimed |
| US-20080312205-A1 | METHOD AND INTERMEDIATES FOR THE PREPARATION OF DERIVATIVES OF N (1-BENZHYDRYLAZETIDIN-3-YL)-N-PHENYLMETHYLSULFONAMIDE | SANOFI-AVENTIS (FR) | 2008-12-18 | — | — | US | claimed |
| US-20070244084-A1 | METHOD AND INTERMEDIATES FOR THE PREPARATION OF DERIVATIVES OF N (1-BENZHYDRYLAZETIDIN-3-YL)-N-PHENYLMETHYLSULFONAMIDE | AVENTIS PHARMA SA (FR) | 2007-10-18 | — | — | US | claimed |
| EP-1802571-A1 | METHOD AND INTERMEDIATES FOR THE PREPARATION OF DERIVATIVES OF N-(1-BENZHYDRYL-AZETIDIN-3-YL)-N-PHENYL-METHYLSULPHONAMIDE | Aventis Pharma S.A. (FR) | 2007-07-04 | — | — | EP | claimed |
| WO-2006040464-A1 | METHOD AND INTERMEDIATES FOR THE PREPARATION OF DERIVATIVES OF N-(1-BENZHYDRYL-AZETIDIN-3-YL)-N-PHENYL-METHYLSULPHONAMIDE | AVENTIS PHARMA S.A. (FR) | 2006-04-20 | — | — | WO | claimed |
| US-8071788-B2 | Method and intermediates for the preparation of derivatives of N-(1-benzhydrylazetidin-3-yl)-N-phenylmethylsulfonamide | SANOFI-AVENTIS (FR) | 2011-12-06 | — | — | US | disclosed |
| EP-1802571-B1 | METHOD AND INTERMEDIATES FOR THE PREPARATION OF DERIVATIVES OF N-(1-BENZHYDRYL-AZETIDIN-3-YL)-N-PHENYL-METHYLSULPHONAMIDE | AVENTIS PHARMA SA (FR) | 2011-11-23 | — | — | EP | disclosed |
| US-20100087414-A1 | METHOD AND INTERMEDIATES FOR THE PREPARATION OF DERIVATIVES OF N (1-BENZHYDRYLAZETIDIN-3-YL)-N-PHENYLMETHYLSULFONAMIDE | SANOFI-AVENTIS (FR) | 2010-04-08 | — | — | US | disclosed |
| US-7652154-B2 | Method and intermediates for the preparation of derivatives of N (1-benzhydrylazetidin-3-yl)-N-phenylmethylsulfonamide | SANOFI-AVENTIS (FR) | 2010-01-26 | — | — | US | disclosed |
| US-20080312205-A1 | METHOD AND INTERMEDIATES FOR THE PREPARATION OF DERIVATIVES OF N (1-BENZHYDRYLAZETIDIN-3-YL)-N-PHENYLMETHYLSULFONAMIDE | SANOFI-AVENTIS (FR) | 2008-12-18 | — | — | US | disclosed |
| US-7429668-B2 | Method and intermediates for the preparation of derivatives of N-(1-benzhydrylazetidin-3-yl)-N-phenylmethylsulfonamide | SANOFI-AVENTIS (FR) | 2008-09-30 | — | — | US | disclosed |
| US-20070244084-A1 | METHOD AND INTERMEDIATES FOR THE PREPARATION OF DERIVATIVES OF N (1-BENZHYDRYLAZETIDIN-3-YL)-N-PHENYLMETHYLSULFONAMIDE | AVENTIS PHARMA SA (FR) | 2007-10-18 | — | — | US | disclosed |
| EP-1802571-A1 | METHOD AND INTERMEDIATES FOR THE PREPARATION OF DERIVATIVES OF N-(1-BENZHYDRYL-AZETIDIN-3-YL)-N-PHENYL-METHYLSULPHONAMIDE | Aventis Pharma S.A. (FR) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006040464-A1 | METHOD AND INTERMEDIATES FOR THE PREPARATION OF DERIVATIVES OF N-(1-BENZHYDRYL-AZETIDIN-3-YL)-N-PHENYL-METHYLSULPHONAMIDE | AVENTIS PHARMA S.A. (FR) | 2006-04-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100087414-A1 | METHOD AND INTERMEDIATES FOR THE PREPARATION OF DERIVATIVES OF N (1-BENZHYDRYLAZETIDIN-3-YL)-N-PHENYLMETHYLSULFONAMIDE | NPEPPS, DHPS, NISCH | CNR1 2384/4885HSD17B10 3961/4885HDAC4 3685/4885 |
| US-20070244084-A1 | METHOD AND INTERMEDIATES FOR THE PREPARATION OF DERIVATIVES OF N (1-BENZHYDRYLAZETIDIN-3-YL)-N-PHENYLMETHYLSULFONAMIDE | NPEPPS, DHPS, NISCH | CNR1 2384/4885HSD17B10 3961/4885HDAC4 3685/4885 |
| US-20080312205-A1 | METHOD AND INTERMEDIATES FOR THE PREPARATION OF DERIVATIVES OF N (1-BENZHYDRYLAZETIDIN-3-YL)-N-PHENYLMETHYLSULFONAMIDE | NPEPPS, DHPS, NISCH | CNR1 2384/4885HSD17B10 3961/4885HDAC4 3685/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.