Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
| ▸ | WDR91 | A4D1P6 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.30 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17320670 | 0.76 | HSD17B10 (0.46) | HSD17B10SMN1; SMN2ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL18675554 | 0.75 | HSD17B10 (0.62) | HSD17B10ALDH1A1HTTDPP4MCL1 | |
| SCHEMBL18675568 | 0.74 | HSD17B10 (0.45) | HSD17B10ALDH1A1KDM4EDPP4MCL1 | |
| SCHEMBL17315705 | 0.71 | USP9X (0.46) | SMN1; SMN2HPGD | |
| SCHEMBL17315706 | 0.71 | USP9X (0.46) | SMN1; SMN2HPGD | |
| SCHEMBL17321816 | 0.67 | IDO1 (0.47) | HSD17B10ALDH1A1 | |
| SCHEMBL18681903 | 0.67 | HSD17B10 (0.48) | HSD17B10ALDH1A1HTTLMNAGRM5 | |
| SCHEMBL17321362 | 0.67 | NPSR1 (0.47) | HSD17B10SMN1; SMN2ALDH1A1HTTMAPT | |
| SCHEMBL17315683 | 0.62 | USP9X (0.46) | SMN1; SMN2HPGDALDH1A1L3MBTL1KDM4E | |
| SCHEMBL1608427 | 0.62 | VNN1 (0.42) | HTTDPP4POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170088520-A1 | DEUBIQUITINASE INHIBITORS | PHARMAKEA, INC. | 2017-03-30 | — | — | US | disclosed |
| WO-2015187427-A1 | DEUBIQUITINASE INHIBITORS | PHARMAKEA, INC. (US) | 2015-12-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170088520-A1 | DEUBIQUITINASE INHIBITORS | USP30, USP1, USP28 | HSD17B10 2097/4885SMN1; SMN2 1672/4885HPGD 2922/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.