Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GJB2 | P29033 | 4/20 | 0.55 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.46 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.46 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.46 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.46 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | TACR2 | P21452 | 2/20 | 0.43 |
| ▸ | NT5E | P21589 | 1/20 | 0.43 |
| ▸ | GJA1 | P17302 | 2/20 | 0.42 |
| ▸ | BCHE | P06276 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | PDE2A | O00408 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | CDC25B | P30305 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24378581 | 0.89 | GJB2 (0.50) | GJB2SSTR1SSTR2SSTR4SSTR3 | |
| SCHEMBL18896703 | 0.89 | HTR1A (0.52) | GJB2SSTR1SSTR2SSTR4SSTR3 | |
| SCHEMBL21283070 | 0.89 | HTR1A (0.52) | GJB2SSTR1SSTR2SSTR4SSTR3 | |
| SCHEMBL1262772 | 0.89 | HTR1A (0.52) | GJB2SSTR1SSTR2SSTR4SSTR3 | |
| SCHEMBL23744216 | 0.89 | HTR1A (0.52) | GJB2SSTR1SSTR2SSTR4SSTR3 | |
| SCHEMBL20404663 | 0.89 | HTR1A (0.52) | GJB2SSTR1SSTR2SSTR4SSTR3 | |
| SCHEMBL20010200 | 0.89 | HTR1A (0.52) | GJB2SSTR1SSTR2SSTR4SSTR3 | |
| SCHEMBL24378346 | 0.87 | SSTR1 (0.52) | GJB2SSTR1SSTR2SSTR4SSTR3 | |
| SCHEMBL25480956 | 0.87 | SSTR1 (0.52) | GJB2SSTR1SSTR2SSTR4SSTR3 | |
| SCHEMBL21172812 | 0.87 | SSTR1 (0.52) | GJB2SSTR1SSTR2SSTR4SSTR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9821001-B2 | Aminoglycosides and uses thereof in the treatment of genetic disorders | TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED (IL) | 2017-11-21 | — | — | US | disclosed |
| US-20150352136-A1 | NOVEL AMINOGLYCOSIDES AND USES THEREOF IN THE TREATMENT OF GENETIC DISORDERS | TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED (IL) | 2015-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150352136-A1 | NOVEL AMINOGLYCOSIDES AND USES THEREOF IN THE TREATMENT OF GENETIC DISORDERS | AARS1, NARS1, GOT1 | GJB2 4239/4885SSTR1 4851/4885SSTR2 4859/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.