Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12781894 | 0.88 | POLB (0.73) | POLBKMT2AMEN1CYP1A2CYP3A4 | |
| SCHEMBL31642475 | 0.88 | POLB (0.73) | POLBKMT2AMEN1CYP1A2CYP3A4 | |
| SCHEMBL762466 | 0.82 | MAPT (0.58) | POLBCYP2C19ALDH1A1LMNAMAPT | |
| SCHEMBL12377877 | 0.81 | TSHR (0.61) | KMT2AMEN1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4776950 | 0.81 | ALDH1A1 (0.73) | KMT2AMEN1NPSR1TSHRALDH1A1 | |
| SCHEMBL19002446 | 0.81 | DRD2 (0.60) | KMT2AMEN1NPSR1TSHRALDH1A1 | |
| SCHEMBL23643753 | 0.81 | LMNA (0.52) | POLBKMT2AMEN1CYP1A2CYP3A4 | |
| SCHEMBL19002651 | 0.80 | ADAMTS5 (0.58) | POLBKMT2AMEN1NPSR1TSHR | |
| SCHEMBL22892232 | 0.80 | ALDH1A1 (0.53) | KMT2AMEN1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL22828073 | 0.80 | GPR119 (0.59) | POLBNPSR1TSHRALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150353495-A1 | NICOTINAMIDES AS JAK KINASE MODULATORS | ALEXION PHARMACEUTICALS, INC. | 2015-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150353495-A1 | NICOTINAMIDES AS JAK KINASE MODULATORS | JAK2, JAK1, NADK | POLB 2890/4885KMT2A 1713/4885MEN1 2476/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.