Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.48 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.48 |
| ▸ | NMT2 | O60551 | 2/20 | 0.47 |
| ▸ | NMT1 | P30419 | 2/20 | 0.47 |
| ▸ | CHRND | Q07001 | 6/20 | 0.46 |
| ▸ | CHRNA1 | P02708 | 2/20 | 0.46 |
| ▸ | CHRNG | P07510 | 2/20 | 0.46 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.45 |
| ▸ | PRKACA | P17612 | 1/20 | 0.45 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.45 |
| ▸ | TLR2 | O60603 | 1/20 | 0.44 |
| ▸ | GRIA1 | P42261 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL254293 | 1.00 | SIRT6 (0.48) | SIRT6SIRT1NMT2NMT1CHRND | |
| SCHEMBL20752792 | 0.91 | NMT1 (0.41) | SIRT6SIRT1NMT2NMT1CHRND | |
| SCHEMBL19982268 | 0.90 | NMT2 (0.40) | SIRT6SIRT1NMT2NMT1CHRND | |
| SCHEMBL14704041 | 0.90 | ROCK2 (0.41) | SIRT6SIRT1NMT2NMT1CHRND | |
| SCHEMBL12284049 | 0.89 | GLP1R (0.39) | SIRT6SIRT1NMT2NMT1ROCK2 | |
| SCHEMBL18893551 | 0.86 | SIRT6 (0.50) | SIRT6SIRT1TLR2 | |
| SCHEMBL16152402 | 0.86 | GLP1R (0.41) | NMT2NMT1ROCK2PRKACAAKT3 | |
| SCHEMBL25062575 | 0.86 | SIRT6 (0.53) | SIRT6SIRT1NMT2NMT1CHRND | |
| SCHEMBL19429720 | 0.85 | ALB (0.47) | ROCK2PRKACAAKT3TLR2 | |
| SCHEMBL25062576 | 0.85 | NMT1 (0.48) | SIRT6SIRT1NMT2NMT1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015188110-A1 | REVERSIBLE PEGYLATION FOR SCREEING OF THERAPEUTIC PROTEINS IN VIVO | THE JOHNS HOPKINS UNIVERSITY (US) | 2015-12-10 | — | — | WO | disclosed |