Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15374625 | 1.00 | LMNA (0.55) | LMNAHTTTSHRNPSR1L3MBTL1 | |
| SCHEMBL17328698 | 0.82 | HDAC11 (0.52) | LMNAHTTKMT2AMEN1 | |
| SCHEMBL17328699 | 0.82 | HDAC11 (0.52) | LMNAHTTKMT2AMEN1 | |
| SCHEMBL17328696 | 0.82 | HDAC11 (0.52) | LMNAHTTKMT2AMEN1 | |
| SCHEMBL15374623 | 0.78 | METAP2 (0.55) | LMNATSHRNPSR1KMT2AMEN1 | |
| SCHEMBL17328440 | 0.78 | METAP2 (0.55) | LMNATSHRNPSR1KMT2AMEN1 | |
| SCHEMBL17328693 | 0.77 | METAP2 (0.54) | MAPK1ALDH1A1 | |
| SCHEMBL15374610 | 0.77 | METAP2 (0.54) | MAPK1ALDH1A1 | |
| SCHEMBL17328599 | 0.76 | METAP2 (0.56) | KMT2AMEN1 | |
| SCHEMBL15374609 | 0.76 | METAP2 (0.56) | KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2627631-B1 | PYRROLIDINONES AS METAP2 INHIBITORS | MERCK PATENT GMBH (DE) | 2015-12-16 | — | — | EP | claimed |