Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.52 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.47 |
| ▸ | METAP2 | P50579 | 10/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17328696 | 1.00 | HDAC11 (0.52) | HDAC11CYP17A1METAP2NOTUMALKBH5 | |
| SCHEMBL17328698 | 1.00 | HDAC11 (0.52) | HDAC11CYP17A1METAP2NOTUMALKBH5 | |
| SCHEMBL17328560 | 0.84 | LIPE (0.49) | HDAC11METAP2NOTUM | |
| SCHEMBL17328558 | 0.84 | LIPE (0.49) | HDAC11METAP2NOTUM | |
| SCHEMBL17328642 | 0.83 | METAP2 (0.62) | METAP2 | |
| SCHEMBL17328707 | 0.83 | METAP2 (0.62) | METAP2 | |
| SCHEMBL17328645 | 0.83 | METAP2 (0.62) | METAP2 | |
| SCHEMBL17328592 | 0.82 | LMNA (0.55) | LMNAHTTMEN1KMT2A | |
| SCHEMBL15374625 | 0.82 | LMNA (0.55) | LMNAHTTMEN1KMT2A | |
| SCHEMBL15367315 | 0.81 | METAP2 (0.63) | METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2627631-B1 | PYRROLIDINONES AS METAP2 INHIBITORS | MERCK PATENT GMBH (DE) | 2015-12-16 | — | — | EP | claimed |