Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.50 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | ALPL | P05186 | 1/20 | 0.47 |
| ▸ | ALPI | P09923 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16980536 | 0.95 | POLB (0.59) | HRH3POLBHDAC1CXCR4CXCL12 | |
| SCHEMBL16980401 | 0.91 | RAB9A (0.53) | HRH3POLBNPC1RAB9A | |
| SCHEMBL10953965 | 0.85 | HRH3 (0.88) | HRH3POLBHDAC1CXCR4CXCL12 | |
| SCHEMBL8319121 | 0.84 | CCR2 (0.49) | HRH3POLBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL14850003 | 0.83 | SMN1; SMN2 (0.49) | HRH3POLBSMN1; SMN2RAB9AOPRM1 | |
| SCHEMBL5864236 | 0.80 | HRH3 (0.72) | HRH3POLBHDAC1CXCR4CXCL12 | |
| SCHEMBL17335877 | 0.80 | HRH3 (0.72) | HRH3POLBHDAC1CXCR4CXCL12 | |
| SCHEMBL11615671 | 0.80 | POLB (0.93) | HRH3POLBHDAC1CXCR4CXCL12 | |
| SCHEMBL5863714 | 0.80 | POLB (0.93) | HRH3POLBHDAC1CXCR4CXCL12 | |
| SCHEMBL4600037 | 0.80 | HRH3 (0.72) | HRH3POLBHDAC1CXCR4CXCL12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170114029-A1 | TREATMENT OF CHAGAS DISEASE | SYNGENE INTERNATIONAL LIMITED (IN) | 2017-04-27 | — | — | US | disclosed |
| WO-2015189595-A1 | TREATMENT OF CHAGAS DISEASE | UNIVERSITY OF DUNDEE (GB) | 2015-12-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170114029-A1 | TREATMENT OF CHAGAS DISEASE | CXCR4, CBR1, CHRM1 | HRH3 34/4885POLB 3304/4885HDAC1 621/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.