Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.38 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.37 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 6/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.34 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.34 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1733931 | 0.80 | MAP3K5 (0.52) | MAP3K5PIK3CAPIK3CGALDH1A1ALDH1A3 | |
| SCHEMBL1733339 | 0.76 | ALDH1A3 (0.38) | MAP3K5ALDH1A1ALDH1A3ALDH1A2EGLN1 | |
| SCHEMBL1733882 | 0.76 | LRRK2 (0.40) | MAP3K5ALDH1A1ALDH1A3ALDH1A2EGLN1 | |
| SCHEMBL1733988 | 0.76 | MAP3K5 (0.51) | MAP3K5ALDH1A1ALDH1A3ALDH1A2EGLN1 | |
| SCHEMBL1733303 | 0.74 | ALDH1A1 (0.38) | PIK3CAALDH1A1ALDH1A3ALDH1A2EGLN1 | |
| SCHEMBL3773678 | 0.73 | KDM4E (0.55) | MAP3K5PIK3CAPIK3CGALDH1A1EGLN1 | |
| SCHEMBL15418924 | 0.73 | ALDH1A1 (0.37) | MAP3K5ALDH1A1ALDH1A3ALDH1A2EGLN1 | |
| SCHEMBL15418882 | 0.73 | ALDH1A1 (0.37) | MAP3K5PIK3CAALDH1A1ALDH1A3ALDH1A2 | |
| SCHEMBL1735826 | 0.73 | ADORA2A (0.59) | ALDH1A1ALDH1A3ALDH1A2EGLN1KDM4E | |
| SCHEMBL1733971 | 0.73 | NR4A2 (0.59) | ALDH1A1ALDH1A3ALDH1A2EGLN1NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225240-B1 | Derivatives of 6-heterocyclic-imidazo[1,2-a]pyridine-2-carboxamides, preparation thereof and therapeutic application thereof | SANOFI SA (FR) | 2014-01-22 | — | — | EP | claimed |
| EP-2225243-B1 | Derivatives of N-heterocyclic-6-heterocyclic-imidazo[1,2-a]pyridine-2-carboxamides, preparation thereof and therapeutic application thereof | SANOFI SA (FR) | 2011-11-16 | — | — | EP | claimed |