SCHEMBL17344397

SCHEMBL17344397

O=C(Nc1ccccc1)OC12CC3CC(C1)CC(OC(=O)Nc1ccccc1)(C3)C2

nearest known ligand 0.53

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 2/20 0.53
P2RX7 Q99572 4/20 0.50
EPHX2 P34913 3/20 0.50
SMN1; SMN2 Q16637 2/20 0.46
LMNA P02545 1/20 0.46
MC4R P32245 1/20 0.46
DPP8 Q6V1X1 7/20 0.44
DPP9 Q86TI2 7/20 0.44
GLMN Q92990 1/20 0.44
ALDH1A1 P00352 1/20 0.42
GAA P10253 1/20 0.42
HTT P42858 1/20 0.42
PGR P06401 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28562936 0.92 DPP4 (0.50) DPP4P2RX7EPHX2SMN1; SMN2LMNA
SCHEMBL8736764 0.91 EPHX2 (0.56) DPP4P2RX7EPHX2SMN1; SMN2LMNA
SCHEMBL17344417 0.91 EPHX2 (0.45) DPP4P2RX7EPHX2SMN1; SMN2LMNA
SCHEMBL3361162 0.90 DPP4 (0.49) DPP4P2RX7EPHX2SMN1; SMN2LMNA
SCHEMBL12745477 0.79 MGLL (0.54) P2RX7EPHX2
SCHEMBL12745770 0.77 EPHX2 (0.57) P2RX7EPHX2ALDH1A1GAA
SCHEMBL17344396 0.76 FAAH (0.45) P2RX7EPHX2LMNADPP8DPP9
SCHEMBL12826766 0.76 P2RX7 (0.53) P2RX7EPHX2ALDH1A1
SCHEMBL12745752 0.76 NPC1 (0.61) EPHX2SMN1; SMN2ALDH1A1HTTPGR
SCHEMBL13893813 0.76 MAPT (0.48) P2RX7EPHX2GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150362847-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2015-12-17 US disclosed
US-20150362847-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2015-12-17 US disclosed