Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17268491 | 0.82 | ALDH1A1 (0.32) | ALDH1A1GAA | |
| SCHEMBL15832231 | 0.80 | RAB9A (0.41) | GABRG2GABRB3GABRA5GABRA3ALDH1A1 | |
| SCHEMBL15819955 | 0.79 | GABRG2 (0.35) | GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL17356160 | 0.77 | CASR (0.38) | — | |
| SCHEMBL15837155 | 0.77 | GABRG2 (0.33) | GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL15980629 | 0.73 | ABCB11 (0.47) | ALDH1A1 | |
| SCHEMBL16269777 | 0.73 | NOTUM (0.34) | — | |
| SCHEMBL15935021 | 0.72 | GABRA1 (0.41) | GABRG2GABRB3GABRA5GABRA3ALDH1A1 | |
| SCHEMBL17238509 | 0.70 | — | — | |
| SCHEMBL19132899 | 0.69 | NOTUM (0.40) | GABRG2GABRB3GABRA5GABRA3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9914727-B2 | Factor IXa inhibitors | MERCK SHARP & DOHME CORP. (US) | 2018-03-13 | — | — | US | disclosed |
| US-9695198-B2 | Factor IXa inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-07-04 | — | — | US | disclosed |
| US-9695198-B2 | Factor IXa inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-07-04 | — | — | US | disclosed |
| US-20150368269-A1 | Factor IXa Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2015-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150368269-A1 | Factor IXa Inhibitors | F9, TFPI, F13B | GABRG2 1868/4885GABRB3 1811/4885GABRA5 1765/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.