Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MPO | P05164 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5517274 | 0.79 | ALDH1A1 (0.37) | KDM4EMPOGAASMN1; SMN2HIF1A | |
| SCHEMBL14439039 | 0.77 | ALDH1A1 (0.40) | KDM4EMPOGAASMN1; SMN2HIF1A | |
| SCHEMBL1875182 | 0.76 | DHODH (0.44) | HDAC6HDAC8HDAC2HDAC4HDAC1 | |
| SCHEMBL17356908 | 0.74 | HDAC6 (0.41) | HDAC6HDAC8HDAC2HDAC4HDAC1 | |
| SCHEMBL8321167 | 0.74 | HDAC8 (0.41) | HDAC6HDAC8HDAC2HDAC4HDAC1 | |
| SCHEMBL29008433 | 0.74 | — | — | |
| SCHEMBL1165189 | 0.72 | HCAR2 (0.33) | KDM4EGAASLC6A3 | |
| SCHEMBL13933872 | 0.71 | SLC6A3 (0.49) | SLC6A3 | |
| SCHEMBL9562844 | 0.70 | DHODH (0.55) | HDAC6HDAC8HDAC2KDM4EGAA | |
| SCHEMBL12168628 | 0.70 | SLC6A3 (0.31) | SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10793538-B2 | Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors | THE BROAD INSTITUTE, INC. (US) | 2020-10-06 | — | — | US | disclosed |
| US-20180215726-A1 | CYCLOALKENYL HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS | THE BROAD INSTITUTE, INC. (US) | 2018-08-02 | — | — | US | disclosed |
| US-20180215726-A1 | CYCLOALKENYL HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS | THE BROAD INSTITUTE, INC. (US) | 2018-08-02 | — | — | US | disclosed |
| US-9914717-B2 | Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors | THE BROAD INSTITUTE, INC. (US) | 2018-03-13 | — | — | US | disclosed |
| US-9914717-B2 | Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors | THE BROAD INSTITUTE, INC. (US) | 2018-03-13 | — | — | US | disclosed |
| US-20150368221-A1 | CYCLOALKENYL HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS | THE BROAD INSTITUTE, INC. | 2015-12-24 | — | — | US | disclosed |
| US-20150368221-A1 | CYCLOALKENYL HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS | THE BROAD INSTITUTE, INC. | 2015-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180215726-A1 | CYCLOALKENYL HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS | HDAC1, HDAC3, HDAC7 | HDAC6 9/4885HDAC8 8/4885HDAC2 7/4885 |
| US-20150368221-A1 | CYCLOALKENYL HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS | HDAC1, HDAC3, HDAC7 | HDAC6 10/4885HDAC8 9/4885HDAC2 7/4885 |
| US-10793538-B2 | Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors | HDAC1, HDAC3, HDAC7 | HDAC6 9/4885HDAC8 8/4885HDAC2 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.